Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility

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• 作者：Xiaolong Ge ; Chao Ding ; Wei Zhao ; Lizhi Xu…
• 关键词：Intestinal microbiota ; Antibiotics ; Gut motility ; Serotonin ; Bile acids
• 刊名：Journal of Translational Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：2900KB
• 刊物主题：Biomedicine, general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1479-5876
• 卷排序：15

文摘

BackgroundThe gastrointestinal motility is affected by gut microbiota and the relationship between them has become a hot topic. However, mechanisms of microbiota in regulating motility have not been well defined. We thus investigated the effect of microbiota depletion by antibiotics on gastrointestinal motility, colonic serotonin levels, and bile acids metabolism.