From Simple to Complex Ca 2+ Oscillations: Regulatory Mechanisms and Theoretical Models

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• 作者：G. Dupont ^AID1 ; G. Houart ^AID1 ; A. Goldbeter ^AID1
• 刊名：Lecture Notes in Physics
• 出版年：2003
• 出版时间：2003
• 年：2003
• 卷：623
• 期：1
• 页码：pp.131-152
• 全文大小：3,649 KB
• 刊物类别：Physics and Astronomy
• 刊物主题：Physics
  Mathematical Methods in Physics
  Mathematical and Computational Physics
  Astronomy, Astrophysics and Cosmology
  Atoms, Molecules, Clusters and Plasmas
  Relativity and Cosmology
  Extraterrestrial Physics and Space Sciences
  Condensed Matter
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1616-6361

文摘

Intracellular Ca ²⁺ oscillations most often appear as regular spikes. However, complex Ca ²⁺ oscillations in the form of bursting or chaos have also been observed. These oscillations most probably originate from the interplay between multiple regulatory mechanisms. From an experimental point of view, the mechanism underlying these types of Ca ²⁺ oscillations remain poorly understood. In this review, we first briefly review the various types of regulatory mechanism known to regulate Ca ²⁺ oscillations, together with the related theoretical models. We show that the interplay between the activation of an InsP3-metabolizing enzyme ( InsP ₃ 3-kinase) by Ca ²⁺ and Ca ²⁺-induced Ca ²⁺ release is a plausible explanation for at least some complex Ca ²⁺ oscillations. This regulation indeed provides a mechanism for the self-modulation of the InsP ₃ signal, thus leading to a phenomenon analogous to the periodic forcing of an autonomous oscillator. We also briefly assess the role of luminal Ca ²⁺ in the onset of Ca ²⁺ oscillations, as well as the link between bistability and Ca ²⁺ oscillations.