Influence of an acetate- and a lactate-based balanced infusion solution on acid base physiology and hemodynamics: an observational pilot study

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• 作者：Klaus F Hofmann-Kiefer (1)
  Daniel Chappell (1)
  Tobias Kammerer (1)
  Matthias Jacob (1)
  Michaela Paptistella (1)
  Peter Conzen (1)
  Markus Rehm (1)
  
• 关键词：Acetate ; Lactate ; Balanced infusion solution ; Acid–base balance ; Hemodynamic stability
• 刊名：European Journal of Medical Research
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：17
• 期：1
• 全文大小：224KB
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• 作者单位：Klaus F Hofmann-Kiefer (1)
  Daniel Chappell (1)
  Tobias Kammerer (1)
  Matthias Jacob (1)
  Michaela Paptistella (1)
  Peter Conzen (1)
  Markus Rehm (1)
  
  1. Clinic of Anesthesiology, Ludwig-Maximilians University, City of Munich, Germany
  
• ISSN：2047-783X

文摘

Background The current pilot study compares the impact of an intravenous infusion of Ringer’s lactate to an acetate-based solution with regard to acid–base balance. The study design included the variables of the Stewart approach and focused on the effective strong ion difference. Because adverse hemodynamic effects have been reported when using acetate buffered solutions in hemodialysis, hemodynamics were also evaluated. Methods Twenty-four women who had undergone abdominal gynecologic surgery and who had received either Ringer’s lactate (Strong Ion Difference 28 mmol/L; n--2) or an acetate-based solution (Strong Ion Difference 36.8 mmol/L; n--2) according to an established clinical protocol and its precursor were included in the investigation. After induction of general anesthesia, a set of acid–base variables, hemodynamic values and serum electrolytes was measured three times during the next 120 minutes. Results Patients received a mean dose of 4,054?±-50 ml of either one or the other of the solutions. In terms of mean arterial blood pressure and norepinephrine requirements there were no differences to observe between the study groups. pH and serum HCO3 - concentration decreased slightly but significantly only with Ringer’s lactate. In addition, the acetate-based solution kept the plasma effective strong ion difference more stable than Ringer’s lactate. Conclusions Both of the solutions provided hemodynamic stability. Concerning consistency of acid base parameters none of the solutions seemed to be inferior, either. Whether the slight advantages observed for the acetate-buffered solution in terms of stability of pH and plasma HCO3 - are clinically relevant, needs to be investigated in a larger randomized controlled trial.