Tissue-independent and tissue-specific patterns of DNA methylation alteration in cancer
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- 作者：Yuting Chen ; Charles E. Breeze ; Shao Zhen ; Stephan Beck…
- 关键词：DNA methylation ; Cancer ; Histone ; Bivalency ; Chromatin
- 刊名：Epigenetics & Chromatin
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：9
- 期：1
- 全文大小：1,672 KB
- 刊物主题：Animal Genetics and Genomics; Human Genetics; Plant Genetics & Genomics; Cell Biology;
- 出版者：BioMed Central
- ISSN：1756-8935
文摘
Background There is growing evidence that DNA methylation alterations contribute to carcinogenesis. While cancer tissue exhibits widespread DNA methylation changes, the proportion of tissue-specific versus tissue-independent DNA methylation alterations in cancer is unclear. In addition, it is unknown which factors determine the patterns of aberrant DNA methylation in cancer.