Serum Lactate Dehydrogenase in Non-Hodgkin's Lymphoma: A Prognostic Indicator

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• 作者：Charu Yadav ; Afzal Ahmad ; Benedicta D'Souza…
• 关键词：Lactate dehydrogenase (LDH) ; Non ; Hodgkin’s lymphoma (NHL)
• 刊名：Indian Journal of Clinical Biochemistry
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：31
• 期：2
• 页码：240-242
• 全文大小：308 KB
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• 作者单位：Charu Yadav (1)
  Afzal Ahmad (1)
  Benedicta D’Souza (1)
  Ashish Agarwal (1)
  M Nandini (1)
  K Ashok Prabhu (1)
  Vivian D’Souza (2)
  
  1. Department of Biochemistry, Kasturba Medical College, Manipal University, Mangalore, 575004, India
  2. Department of Biochemistry, Kanachur Institute of Medical Science, Deralakatte, Mangalore, India
  
• 刊物主题：Biochemistry, general; Microbiology; Chemistry/Food Science, general; Pathology;
• 出版者：Springer India
• ISSN：0974-0422

文摘

Non-Hodgkin’s lymphoma constitutes a group of disorders originating from the malignant transformation of lymphocytes and involving either the lymph nodes or extranodal sites. NHL commonly presents in the sixth to seventh decade of life with a male preponderance (50–75 %). Recent studies have shown importance of serum LDH in prognosis of NHL. Authors report a case of a 63 year old male presenting with complaints of fever and backache for past 4 months. General and systemic examination revealed bilateral axillary lymphadenopathy and splenomegaly respectively. Serum LDH level was highly elevated (3441 U/l). Excisional axillary and bone marrow biopsy were done before oncology referral. Complete workup revealed diffuse Non-Hodgkin’s lymphoma with bone marrow infiltration. Patient died because of acute renal failure due to NHL and DM 2 (Type 2 diabetes mellitus).