Emerging Tissue and Blood-Based Biomarkers that may Predict Response to Immune Checkpoint Inhibition
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  • 作者:Claire F. Friedman ; Michael A. Postow
  • 关键词:Immunotherapy ; Checkpoint blockade ; Ipilimumab ; Nivolumab ; Pembrolizumab ; Biomarkers ; PD ; 1 ; PD ; L1 ; CTLA ; 4 ; Neoantigens ; Melanoma
  • 刊名:Current Oncology Reports
  • 出版年:2016
  • 出版时间:April 2016
  • 年:2016
  • 卷:18
  • 期:4
  • 全文大小:287 KB
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  • 作者单位:Claire F. Friedman (1)
    Michael A. Postow (1)

    1. Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA
  • 刊物主题:Oncology;
  • 出版者:Springer US
  • ISSN:1534-6269
  • 文摘
    The immune system plays an essential role in the surveillance and eradication of neoplastic cells. This interaction is modulated via immunologic regulators (checkpoints). Antibodies that block the checkpoints cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), and the programmed cell death protein 1 pathway (PD1/PD-L1) have demonstrated efficacy in a number of malignancies. However, response rates are variable, and administration of these antibodies can be associated with immune-related adverse events. Therefore, researchers are engaged in an effort to discover biomarkers that may predict response to these agents. This review focuses on potential blood and tumor-based biomarkers that have been assessed in patients treated with these checkpoint-blocking antibodies.

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