Arrested growth and spontaneous tumor regression of partially resected low-grade cerebellar astrocytomas in children

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• 作者：Joon-Khim Loh (1) (2) (3)
  Ann-Shung Lieu (1) (2)
  Chee-Yin Chai (4)
  Shiuh-Lin Hwang (1) (2)
  Aij-Lie Kwan (1) (2)
  Chih-Jen Wang (1) (2)
  Shen-Long Howng (1) (2)
  
• 关键词：Cerebellar astrocytoma ; Tumor regression ; Magnetic resonance imaging ; Radiation therapy
• 刊名：Child's Nervous System
• 出版年：2013
• 出版时间：November 2013
• 年：2013
• 卷：29
• 期：11
• 页码：2051-2055
• 全文大小：
• 作者单位：Joon-Khim Loh (1) (2) (3)
  Ann-Shung Lieu (1) (2)
  Chee-Yin Chai (4)
  Shiuh-Lin Hwang (1) (2)
  Aij-Lie Kwan (1) (2)
  Chih-Jen Wang (1) (2)
  Shen-Long Howng (1) (2)
  
  1. Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, No 100 Tzyou 1 Rood, Kaohsiung, 807, Taiwan
  2. Faculty of Medicine, Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  3. Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
  4. Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  
• ISSN：1433-0350

文摘

Purpose The prognosis of children with low-grade cerebellar astrocytoma who have partial resection of tumor is largely unpredictable. The purpose of this study was to review the long-term outcome of such patients. Methods The medical charts, imaging findings, operative notes, histopathological reports, and survival times of 12 patients with cerebellar astrocytoma were reviewed. Results Five patients had total resection and seven had partial resection. Nine patients had grade I histology and three patients had grade II. Follow-up duration ranged from 3 to 25?years. Among the seven patients with residual tumor, five had tumor progression, one had arrested tumor growth, and one had spontaneous tumor regression. Five patients with partial resection received radiotherapy and three had malignant transformation of tumor during follow-up. Six patients, including five who had partial resection, underwent a second operation. One patient with partial resection died of pneumonia 23?years after surgery. Conclusions Patients with complete tumor resection had a better prognosis than patients with partial resection. For patients with partial resection, we recommend a ?ait and see?policy with surveillance using MRI. The phenomenon of arrested tumor growth and spontaneous tumor regression in patients with cerebellar astrocytoma who have subtotal resection warrants further study.