Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr-immuno-PET
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- 作者：Danielle J. Vugts ; Chris Klaver…
- 关键词：Immuno ; PET ; 89Zr ; DFO* ; DFO ; Monoclonal antibodies
- 刊名：European Journal of Nuclear Medicine and Molecular Imaging
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：44
- 期：2
- 页码：286-295
- 全文大小：729KB
- 刊物类别：Medicine
- 刊物主题：Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1619-7089
- 卷排序：44
文摘
PurposeAll clinical 89Zr-immuno-PET studies are currently performed with the chelator desferrioxamine (DFO). This chelator provides hexadentate coordination to zirconium, leaving two coordination sites available for coordination with, e.g., water molecules, which are relatively labile ligands. The unsaturated coordination of DFO to zirconium has been suggested to result in impaired stability of the complex in vivo and consequently in unwanted bone uptake of 89Zr. Aiming at clinical improvements, we report here on a bifunctional isothiocyanate variant of the octadentate chelator DFO* and the in vitro and in vivo comparison of its 89Zr-DFO*-mAb complex with 89Zr-DFO-mAb.