Synthetic and natural antioxidants attenuate cisplatin-induced vomiting
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- 作者：Javaid Alam ; Fazal Subhan ; Ihsan Ullah ; Muhammad Shahid…
- 关键词：Emesis ; Antiemetic ; Chemotherapy ; Bacopa monnieri ; Grape seed proanthocyanidin ; N ; (2 ; mercaptopropionyl) glycine ; Vitamin C ; Free radical scavenging assay ; Correlation
- 刊名：BMC Pharmacology and Toxicology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：861KB
- 刊物主题：Pharmacology/Toxicology;
- 出版者：BioMed Central
- ISSN：2050-6511
- 卷排序：18
文摘
BackgroundSynthetic and natural antioxidants including Bacopa monnieri (L.) Pennell (Scrophulariaceae) which also possess anti-dopaminergic properties, have been proposed to be useful for emetogenic chemotherapy. In this study, synthetic [N-(2-mercaptopropionyl) glycine (MPG), vitamin C (Vit-C)] and natural [grape seed proanthocyanidin (GP), B. monnieri n-butanolic fraction (BM-ButFr)] antioxidants and their combinations were evaluated against cisplatin-induced emesis in pigeons during a 24 h observation period.