Hydantoinasen – von der präbiotischen Evolution zur Aminosäureproduktion

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• 作者：Jens Rudat ; Ulrike Engel
• 刊名：BIOspektrum
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：23
• 期：1
• 页码：98-100
• 全文大小：
• 刊物主题：Life Sciences, general; Biochemistry, general; Human Genetics; Microbiology; Developmental Biology; Pharmacology/Toxicology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1868-6249
• 卷排序：23

文摘

The hydantoinase process is used for the large-scale production of optically pure amino acids, with side chains of semisynthetic penicillins as the most prominent products. The origin as well as the natural function of the eponymous enzymes, however, remains unclear to this day. Here we discuss the way of hydantoinases from prebiotic evolution to directed evolution, spanning some billion years from the origin of life to industrial processes.