Mean platelet volume in patients with fibromyalgia

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• 作者：Dr. S. Halilo臒lu (1)
  A. Carlioglu (2)
  E. Sahiner (3)
  Y. Karaaslan (4)
  A. Kosar (5)
  
• 关键词：Fibromyalgia ; Mean platelet volume ; Cardiovascular diseases ; Risk factors ; Platelet activation ; Fibromyalgie ; Mittleres Thrombozytenvolumen ; Kardiovaskul盲re Erkrankungen ; Risikofaktoren ; Pl盲ttchenaktivierung
• 刊名：Zeitschrift f篓鹿r Rheumatologie
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：73
• 期：8
• 页码：742-745
• 全文大小：284 KB
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• 作者单位：Dr. S. Halilo臒lu (1)
  A. Carlioglu (2)
  E. Sahiner (3)
  Y. Karaaslan (4)
  A. Kosar (5)
  
  1. Department of Physical Medicine and Rehabilitation, Erzurum Regional Research and Training Hospital, 25240, Erzurum, Turkey
  2. Department of Endocrinology, Erzurum Regional Research and Training Hospital, Erzurum, Turkey
  3. Department of Internal Medicine, Faculty of Medicine, Fatih University, Ankara, Turkey
  4. Department of Rheumatology, Ankara Numune Research and Training Hospital, Ankara, Turkey
  5. Department of Hematology, Faculty of Medicine, Fatih University, Ankara, Turkey
  
• ISSN：1435-1250

文摘

Fibromyalgia is a syndrome characterised by chronic widespread pain at multiple tender points, as well as joint stiffness and systemic symptoms. The aetiology and pathogenesis of fibromyalgia still remain unclear, although many contributory factors have been suggested. The presence of some common features between fibromyalgia and cardiovascular risk factors (e.g. depression and sleep disturbance) led to question of whether there is there a relationship between fibromyalgia and cardiovascular disease and/or atherosclerosis. Mean platelet volume, which is a determinant of platelet activation, is a newly emerging independent risk factor for cardiovascular disease. The present study was designed to evaluate levels of mean platelet volume in patients with fibromyalgia; the study population consisted of 283聽individuals with this syndrome, who were compared with 72聽healthy controls. Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count and mean platelet volume levels were retrospectively recorded via the computerised patient database. The levels of mean platelet volume were significantly higher in the fibromyalgia group than in the control group (8.09鈥壜扁€?.84聽fl and 7.73鈥壜扁€?.65聽fl, respectively, p鈥?鈥?.001). There were no statistical differences between groups with regard to platelet count and other parameters. These results suggest that an early atherosclerosis marker, mean platelet volume, is elevated in patients with fibromyalgia. This indicates increased platelet activation and therefore a higher risk of future cardiovascular disease.