Tau passive immunization inhibits not only tau but also Aβ pathology
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- 作者：Chun-ling Dai ; Yunn Chyn Tung ; Fei Liu ; Cheng-Xin Gong…
- 关键词：Alzheimer’s disease ; Amyloid ; β ; Immunotherapy ; Tau ; Tauopathy
- 刊名：Alzheimer's Research & Therapy
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：9
- 期：1
- 全文大小：3562KB
- 刊物主题：Neurosciences; Neurology; Geriatrics/Gerontology; Geriatric Psychiatry;
- 出版者：BioMed Central
- ISSN：1758-9193
- 卷排序：9
文摘
BackgroundAccumulation of hyperphosphorylated tau protein is a histopathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Currently, there is no effective treatment available for these progressive neurodegenerative diseases. In recent years, tau immunotherapy has shown great potential in animal models. We report the effect of immunization with tau antibodies 43D against tau 6–18 and 77E9 against tau 184–195 on tau and amyloid-β (Aβ) pathologies and cognition in triple-transgenic (3×Tg)-AD mice at mild to moderate stages of the disease.