Potential unfavorable impacts of BDNF Val66Met polymorphisms on metabolic risks in average population in a longevous area
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- 作者：Jun-Hua Peng ; Cheng-Wu Liu ; Shang-Ling Pan ; Hua-Yu Wu ; Qing-Hua Liang…
- 关键词：BDNF gene ; Polymorphism ; Metabolic risks ; Longevity ; Correlation
- 刊名：BMC Geriatrics
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：1047KB
- 刊物主题：Geriatrics/Gerontology; Aging; Rehabilitation;
- 出版者：BioMed Central
- ISSN：1471-2318
- 卷排序：17
文摘
BackgroundBrain-derived neurotrophic factor (BDNF) has been implicated in cognitive performance and the modulation of several metabolic parameters in some disease models, but its potential roles in successful aging remain unclear. We herein sought to define the putative correlation between BDNF Val66Met and several metabolic risk factors including BMI, blood pressure, fasting plasma glucose (FPG) and lipid levels in a long-lived population inhabiting Hongshui River Basin in Guangxi.