Paeoniflorin exerts a nephroprotective effect on concanavalin A-induced damage through inhibition of macrophage infiltration
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- 作者：Cheng Liu ; Zhuoan Cheng ; Yunman Wang ; Xiuqin Dai ; Jie Zhang…
- 关键词：Paeoniflorin ; CXCR3 ; CXCL11 ; Macrophage infiltration ; Concanavalin A
- 刊名：Diagnostic Pathology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：10
- 期：1
- 全文大小：2,639 KB
- 刊物主题：Pathology;
- 出版者：BioMed Central
- ISSN：1746-1596
文摘
Background It is well established that macrophage infiltration is involved in concanavalin A (conA)-induced liver injury. However, the role of macrophages in conA-induced renal injury remains unknown. The aims of this study were to investigate macrophage infiltration in conA-induced renal injury and determine whether paeoniflorin (PF) could inhibit macrophage infiltration into the kidney.