Warburg meets non-coding RNAs: the emerging role of ncRNA in regulating the glucose metabolism of cancer cells
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- 作者：Chenxiao Yu ; Jiao Xue ; Wei Zhu ; Yang Jiao ; Shuyu Zhang ; Jianping Cao
- 关键词：Warburg effect ; Aerobic glycolysis ; Glucose metabolism ; Non ; coding RNA (ncRNA) ; MicroRNA (miRNA) ; Long non ; coding RNA (lncRNA)
- 刊名：Tumor Biology
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：36
- 期：1
- 页码：81-94
- 全文大小：825 KB
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Jiao Xue (1) (2)
Wei Zhu (1) (2)
Yang Jiao (1) (2)
Shuyu Zhang (1) (2)
Jianping Cao (1) (2)
1. School of Radiation Medicine and Protection and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, No. 199 Ren’ai Rd, Suzhou, 215123, China
2. Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, 215123, China - 刊物主题：Cancer Research;
- 出版者：Springer Netherlands
- ISSN：1423-0380
文摘
Unlike normal differentiated cells, cancer cells primarily rely on glycolysis to generate energy needed for cellular processes even in normoxia conditions. This phenomenon is called aerobic glycolysis or “the Warburg effect.-Aerobic glycolysis is inefficient to generate ATP, but the advantages it confers to cancer cells remain to be fully explained. Several oncogenic signaling pathways, interplaying with enzymes and kinases involved in glucose metabolism, participate in the switch from oxidative phosphorylation (OXPHOS) to aerobic glycolysis. Non-coding RNAs (ncRNAs) are a family of functional RNA molecules that are not further translated into proteins, which exert regulatatory roles in gene transcription and translation. ncRNAs, especially miRNAs and long non-coding RNAs (lncRNAs), may also have great effect on glucose metabolism by targeting not only glycolysis enzymes directly but also oncogenic signaling pathways indirectly. A better understanding of the Warburg effect and the regulatory role of ncRNAs in cancer glucose metabolism may contribute to the treatment of cancers.