Dermal toxicity study of rice bran supercritical CO2 extract in Sprague-Dawley rats
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- 作者：Jae-Suk Choi ; Eun Jin Cheon ; Tae-Uk Kim ; Woi-Sook Moon…
- 关键词：rice bran ; supercritical CO2 extract ; noobserve ; adverse ; effect level ; dermal toxicity ; rat
- 刊名：Food Science and Biotechnology
- 出版年：2015
- 出版时间：June 2015
- 年：2015
- 卷：24
- 期：3
- 页码：1167-1176
- 全文大小：208 KB
- 参考文献：1.Pourali O. Production of valuable materials from rice bran biomass using subcritical water. PhD thesis, Osaka Prefecture University, Osaka, Japan (2010)
2.Lee JW, Lee SW, Kim MK, Rhee C, Kim IH, Lee KW. Beneficial effect of the unsaponifiable matter from rice bran on oxidative stress in vitro compared with 伪-tocopherol. J. Sci. Food Agr. 85: 493鈥?98 (2005)View Article
3.Prabhakar JV, Venkatesh KVL. A simple chemical method for stabilization of rice bran. J. Am. Oil Chem. Soc. 63: 644鈥?46 (1986)View Article
4.Danielski L, Zetzl C, Hense H, Brunner G. A process line for the production of raffinated rice bran oil from rice bran. J. Supercrit. Fluid. 34: 133鈥?41 (2005)View Article
5.McCaskill DR, Zhang F. Use of rice bran oil in foods: Developing nutraceuticals for the new millenium. Food Technol. 53: 50鈥?3 (1999)
6.Pezzoli G, Ricciardi S, Masotto C, Mariani CB, Carenzi A. n-Hexane induces Parkinsonism in rodents. Brain Res. 531: 355鈥?57 (1990)View Article
7.Karakaya A, Y眉cesoy B, Burgaz S, Sabir HU, Karakaya AE. Some immunological parameters in workers occupationally exposed to n-hexane. Hum. Exp. Toxicol. 15: 56鈥?8 (1996)View Article
8.Yeddes N, Ch茅rif JK, Jrad A, Barth D, Trabelsi-Ayadi M. Supercritical SC-CO2 and soxhlet n-hexane extract of Tunisian Opuntia ficus indica seeds and fatty acids analysis. J. Lipids 2012: 914693 (2012)View Article
9.Sahena F, Zaidul ISM, Jinap S, Karim AA, Abbas KA, Norulaini NAN, Omar AKM. Application of supercritical CO2 in lipid extraction-A review. J. Food Eng. 95: 240鈥?53 (2009)View Article
10.Ruksiriwanich W, Manosroi J, Abe M, Manosroi W, Manosroi A. 5a-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid. J. Supercrit. Fluid. 59: 61鈥?1 (2011)View Article
11.Choi JS, Jeon MH, Moon WS, Moon JN, Cheon EJ, Kim JW, Jung SK, Ji YH, Son SW, Kim MR. In vivo hair growth-promoting effect of rice bran extract prepared by supercritical carbon dioxide fluid. Biol. Pharm. Bull. 37: 44鈥?3 (2014)View Article
12.Choi JS, Moon WS, Moon JM, Cheon EJ, Son SW, Kim JW, Kim MR. Cytotoxicity and single-dose oral toxicity testing for rice bran supercritical CO2 extract. Toxicol. Environ. Health Sci. 5: 215鈥?20 (2013)View Article
13.KFDA. Good Laboratory Practice (GLP) standards. Notification No. 2013鈥?0. Korea Food and Drug Administration, Cheongju, Korea. pp. 1鈥?9 (2013)
14.OECD. Principles of Good Laboratory Practice, ENV/MC/ CHEM(98)17, Organization for Economic Cooperation and Development, Paris, France. pp. 1鈥?1 (1997)
15.OECD. OECD Guideline for Testing of Chemicals- Acute Dermal Toxicity, Guideline No. 402. Organization for Economic Cooperation and Development, Rome, Italy. pp. 1鈥? (1987)
16.OECD. Repeated dose dermal toxicity: 21/28 day study. pp. 1鈥?. In: OECD Guidelines for Testing of Chemicals, No. 410. Organization for Economic Cooperation and Development, Paris, France (1981)
17.Sternheimer R, Malbin BI. A new stain for urinary sediments: its value in the differential diagnosis of hypertension. (Abstr.) Am. Heart J. 37: 678 (1949)
18.Yee AH, Rabinstein AA. Neurologic presentations of acid-base imbalance, electrolyte abnormalities, and endocrine emergencies. Neurol. Clin. 28: 1鈥?6 (2010)View Article
19.Neylon M, Marshall JM, Johns EJ. The effects of chronic hypoxia on renal function in the rat. J. Physiol. 501: 243鈥?50 (1997)View Article
20.Han ZZ, Xu HD, Kim KH, Ahn TH, Bae JS, Lee JY, Gil KH, Lee JY, Woo SJ, Yoo HJ, Lee HK, Kim KH, Park CK, Zhang HS, Song SW. Reference data of the main physiological parameters in control Sprague-Dawley rats from pre-clinical toxicity studies. Lab. Anim. Res. 26: 153鈥?64 (2010)View Article
21.Kohn DF, Clifford CB. Biology and diseases of rats. pp. 121鈥?58. In: Laboratory Animal Medicine. 2nd ed. Fox JG, Anderson LC, Loew FM, Quimby FW (eds). Academic Press, San Diego, CA, USA (2002)View Article
22.Aird B. Acute blood loss anemia. pp. 151鈥?53. In: Schalm鈥檚 Veterinary Hematology. 5th ed. Feldman BF, Schalm OW, Zinkl JG, Jain MC (eds). Lippincott Williams & Wilkins, Baltimore, MD, USA (2000)
23.Fernandez FR, Grindem CB. Reticulocyte Response. pp. 110鈥?16. In: Schalm鈥檚 Veterinary Hematology. 5th ed. Feldman BF, Schalm OW, Zinkl JG, Jain MC (eds). Lippincott Williams & Wilkins, Baltimore, MD, USA (2000)
24.Moore DM. Hematology of the rat (Rattus norvegicus). pp. 1210鈥?218. In: Schalm鈥檚 Veterinary Hematology. 5th ed. Feldman BF, Schalm OW, Zinkl JG, Jain MC (eds). Lippincott Williams & Wilkins, Baltimore, MD, USA (2000)
25.Masaki T, Matsuura T, Ohkawa K, Miyamura T, Okazaki I, Watanabe T, Suzuki T. All-trans retinoic acid down-regulates human albumin gene expression through the induction of C/EBP脽-LIP. Biochem. J. 397: 345鈥?53 (2006)View Article
26.Pasantes-Morales H, Wright CE, Gaull GE. Protective effect of taurine, zinc and tocopherol on retinol-induced damage in human lymphoblastoid cells. J. Nutr. 114: 2256鈥?261 (1984)
27.Seo DS, Kwon M, Sung HJ, Park CB. Acute oral or dermal and repeated dose 90-day oral toxicity of tetrasodium pyrophosphate in Spraque Dawley (SD) rats. Environ. Health Toxicol. 26: e2011014 (2001)
28.Greaves P. Histopathology of preclinical toxicity studies: Interpretation and relevance in drug safety evaluation. Academic Press Inc., Waltham, MA, USA. pp. 1鈥?53 (2007)
29.Boorman GA, Eustis SL, Elwell MR, Montgomery Jr CA, Mackenzie WF. Pathology of the Fischer Rat: Reference and Atlas. 5th ed. Academic Press Inc., Waltham MA, USA. pp. 1鈥?80 (1990)
30.Globally Harmonized System of Classification and Labelling of Chemicals. 5th ed. New York and Geneva, United Nations. pp. 1鈥?61 (2011) - 作者单位：Jae-Suk Choi (1)
Eun Jin Cheon (1)
Tae-Uk Kim (1)
Woi-Sook Moon (2)
Joo-Wan Kim (3)
Mi-Ryung Kim (1)
1. Department of Bio-Food Materials, Silla University, Busan, 617-736, Korea
2. Department of R&D, ECOMINE Co., Ltd, Busan, 608-736, Korea
3. Department of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Korea - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Nutrition
Food Science - 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
- ISSN：2092-6456
文摘
The present study was carried out to evaluate the dermal toxicity of topically administered rice bran supercritical CO2 extract (RB-SCE; 500, 1,000, and 2,000 mg/kg) in male and female rats when given as a single dose and a 4-week repeated dose. In all rats that underwent the single-dose toxicity test, there were no abnormal changes in clinical signs or body weight and no deaths or abnormal gross necropsy findings related to RB-SCE. Based on the above results, the LD50 is >2,000 mg/kg in both sexes. In all rats that underwent the 4-week repeated dermal toxicity test, there were no abnormal RB-SCEassociated changes with respect to external signs, urine and blood, or organs. The no-observed-adverse-effect level (NOAEL) of RB-SCE was thus considered to be 2,000 mg/kg/day for both sexes and the target organ. RB-SCE can be regarded as a very safe agent for topical dermal administration at a moderate dose.