Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes
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- 作者：Hyun Sook Hwang ; Su Jin Park ; Eun Jeong Cheon ; Mi Hyun Lee…
- 关键词：Chondrocyte ; Fibronectin fragment ; MyD88 ; Osteoarthritis ; TLR ; 2
- 刊名：Arthritis Research & Therapy
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：17
- 期：1
- 全文大小：2,041 KB
- 刊物主题：Rheumatology; Orthopedics;
- 出版者：BioMed Central
- ISSN：1478-6354
文摘
Introduction Fibronectin fragments (FN-fs) are increased in the cartilage of patients with osteoarthritis (OA) and have a potent chondrolytic effect. However, little is known about the cellular receptors and signaling mechanisms that are mediated by FN-fs. We investigated whether the 29-kDa amino-terminal fibronectin fragment (29-kDa FN-f) regulates cartilage catabolism via the Toll-like receptor (TLR)-2 signaling pathway in human chondrocytes.