Role of Nitric Oxide and Lipid Peroxidation in Mechanisms of Febrile Convulsions in Wistar Rat Pups
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- 作者：Yu.A. Klyueva ; V.G. Bashkatova ; G.Yu. Vitskova ; V.B. Narkevich ; V.D. Mikoyan ; A.F. Vanin ; S.A. Chepurnov and N.E. Chepurnova
- 关键词：febrile convulsions ; nitric oxide ; N ; nitro ; L ; arginine ; lipid peroxidation ; EPR spectroscopy
- 刊名：Bulletin of Experimental Biology and Medicine
- 出版年：2001
- 出版时间：2001
- 年：2001
- 卷：131
- 期：1
- 页码：47-49
- 全文大小：378 KB
文摘
Generation of nitric oxide and the content of lipid peroxidation products in the brain are increased in rat pups during febrile convulsions. NO-synthase inhibitor N-nitro-L-arginine in a dose of 250 mg/kg prevented hyperthermia-induced accumulation of nitric oxide, increased the latency febrile convulsions, and had no effect on the content of lipid peroxidation products.