Early uptake and continuous accumulation of thallium-201 chloride in a benign mixed tumor of soft tissue: Case Report

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• 作者：Shigenori Nagata (1)
  Yu-Fen Jin (1)
  Katsuhiko Yoshizato (1)
  Masanori Kitamura (1)
  Norishige Iizuka (1)
  Misa Song (1)
  Miki Tomoeda (1)
  Michiko Yuki (1)
  Chiaki Kubo (1)
  Hidenori Yoshizawa (1)
  Hidetatsu Outani (2)
  Kenichiro Hamada (2)
  Nobuhito Araki (2)
  Masahiro Funauchi (3)
  Yasuhiko Tomita (1)
  
• 刊名：Diagnostic Pathology
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：5
• 期：1
• 全文大小：2360KB
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• 作者单位：Shigenori Nagata (1)
  Yu-Fen Jin (1)
  Katsuhiko Yoshizato (1)
  Masanori Kitamura (1)
  Norishige Iizuka (1)
  Misa Song (1)
  Miki Tomoeda (1)
  Michiko Yuki (1)
  Chiaki Kubo (1)
  Hidenori Yoshizawa (1)
  Hidetatsu Outani (2)
  Kenichiro Hamada (2)
  Nobuhito Araki (2)
  Masahiro Funauchi (3)
  Yasuhiko Tomita (1)
  
  1. Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Osaka, 537-8511, Japan
  2. Department of Orthopedics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Osaka, 537-8511, Japan
  3. Department of Nuclear Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari, Osaka, 537-8511, Japan
  

文摘

A case of benign mixed tumor of the soft tissue in a 64-year-old Japanese male is presented. He noticed a painless, elastic hard mass sized 3 cm in the right knee, which gradually grew larger and harder in the last 5 years. Magnetic resonance imaging demonstrated a mass lesion embedded in the subcutaneous tissue with low and high signal intensity at T1- and T2-weighted images, respectively. Tl-201 scintigraphy showed an early uptake of Tl-201 within the lesion at 10 minutes after injection, which was slightly decreased but still continued at 2 hours later. The patient underwent a resection of tumor, and the pathological diagnosis was a benign mixed tumor of soft tissue without high vascularity, characterized by histological features similar to pleomorphic adenomas in the salivary glands. Immunohistochemical study proved expression of Na+/K+-ATPase of tumor cells. Overexpression of Na+/K+-ATPase of the tumor might be responsible for the early uptake of Tl-201, and poor vascular structure in this tumor might lead to continuous accumulation. The Tl-201 scintigraphic features of mixed tumor of soft tissue are assessed to resemble those of malignant soft tissue tumors.