Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58)
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- 作者：Chuan-Pin Yang ; Chi-Wu Chiang ; Chang-Han Chen ; Yi-Chao Lee…
- 关键词：58 ; kDa Microspherule Protein ; Nucleolus ; Nuclear localization signal ; Nucleolar localization signal ; Importins
- 刊名：Journal of Biomedical Science
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：22
- 期：1
- 全文大小：2,098 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Biomedicine - 出版者：Springer Netherlands
- ISSN：1423-0127
文摘
Background MSP58 is a nucleolar protein associated with rRNA transcription and cell proliferation. Its mechanism of translocation into the nucleus or the nucleolus, however, is not entirely known. In order to address this lack, the present study aims to determine a crucial part of this mechanism: the nuclear localization signal (NLS) and the nucleolar localization signal (NoLS) associated with the MSP58 protein.