Biodegradable nanoparticles for gene therapy technology
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- 作者：Hossein Hosseinkhani (1) (3) (4)
Wen-Jie He (1)
Chiao-Hsi Chiang (3)
Po-Da Hong (1) (2)
Dah-Shyong Yu (4) (6)
Abraham J. Domb (5)
Keng-Liang Ou (10) (7) (8) (9) - 关键词：Gene therapy ; Viral vectors ; Non ; viral vectors ; DNA ; Gene expression
- 刊名：Journal of Nanoparticle Research
- 出版年：2013
- 出版时间：July 2013
- 年：2013
- 卷：15
- 期：7
- 全文大小：400 KB
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Wen-Jie He (1)
Chiao-Hsi Chiang (3)
Po-Da Hong (1) (2)
Dah-Shyong Yu (4) (6)
Abraham J. Domb (5)
Keng-Liang Ou (10) (7) (8) (9)
1. Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology (Taiwan Tech), Taipei, 10607, Taiwan
3. School of Pharmacy, National Defense Medical Center, Neihu, Taipei, 11490, Taiwan
4. Nanomedicine Research Center, National Defense Medical Center, Taipei, 114, Taiwan
2. Department of Materials Science and Engineering, National Taiwan University of Science and Technology (Taiwan Tech), Taipei, 10607, Taiwan
6. Division of Urology, Tri-Service General Hospital, Taipei, Taiwan
5. Institute of Drug Research, School of Pharmacy, Faculty of Medicine, Center for Nanoscience and Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, 91120, Jerusalem, Israel
10. Graduate Institute of Biomedical Materials and Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei, 110, Taiwan
7. Research Center for Biomedical Devices and Prototyping Production, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
8. Research Center for Biomedical Implants and Microsurgery Devices, Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
9. Department of Dentistry, Taipei Medical University-Shuang-Ho Hospital, Taipei, 110, Taiwan - ISSN：1572-896X
文摘
Rapid propagations in materials technology together with biology have initiated great hopes in the possibility of treating many diseases by gene therapy technology. Viral and non-viral gene carriers are currently applied for gene delivery. Non-viral technology is safe and effective for the delivery of genetic materials to cells and tissues. Non-viral systems are based on plasmid expression containing a gene encoding a therapeutic protein and synthetic biodegradable nanoparticles as a safe carrier of gene. Biodegradable nanoparticles have shown great interest in drug and gene delivery systems as they are easy to be synthesized and have no side effect in cells and tissues. This review provides a critical view of applications of biodegradable nanoparticles on gene therapy technology to enhance the localization of in vitro and in vivo and improve the function of administered genes.