Increased cerebral activation after behavioral treatment for memory deficits in MS

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• 作者：Nancy D. Chiaravalloti (124) nchiaravalloti@kesslerfoundation.org
  Glenn Wylie (12)
  Victoria Leavitt (12)
  John DeLuca (123)
• 关键词：Cognition – ; fMRI – ; Multiple sclerosis – ; Memory – ; Cognitive rehabilitation
• 刊名：Journal of Neurology
• 出版年：2012
• 出版时间：July 2012
• 年：2012
• 卷：259
• 期：7
• 页码：1337-1346
• 全文大小：513.0 KB
• 参考文献：1. Chelune GJ, Stott H, Pinkston J (2008) Multiple sclerosis in textbook of clinical neuropsychology. Taylor and Francis, New York
  2. Chiaravalloti ND, DeLuca J (2008) Cognitive impairment in multiple sclerosis. Lancet Neurol 7(12):1139–1151
  3. Benedict RH, Zivadinov R (2006) Predicting neuropsychological abnormalities in multiple sclerosis. J Neurol Sci 245(1–2):67–72
  4. Rao SM et al (1993) Memory dysfunction in multiple sclerosis: its relation to working memory, semantic encoding and implicit learning. Neuropsychology 7(3):364–374
  5. DeLuca J, Barbieri-Berger S, Johnson SK (1994) The nature of memory impairments in multiple sclerosis: acquisition versus retrieval. J Clin Exp Neuropsychol 16(2):183–189
  6. DeLuca J et al (1998) Acquisition and storage deficits in multiple sclerosis. J Clin Exp Neuropsychol 20(3):376–390
  7. O’Brien AR et al (2008) Evidenced-based cognitive rehabilitation for persons with multiple sclerosis: a review of the literature. Arch Phys Med Rehabil 89(4):761–769
  8. Allen DN et al (1998) Teaching memory strategies to persons with multiple sclerosis. J Rehabil Res Dev 35(4):405–410
  9. Chiaravalloti ND et al (2005) Treating learning impairments improves memory performance in multiple sclerosis: a randomized clinical trial. Mult Scler 11:58–68
  10. Chiaravalloti ND et al (2005) Cerebral activation patterns during working memory performance in multiple sclerosis using FMRI. J Clin Exp Neuropsychol 27(1):33–54
  11. Mainero C et al (2004) fMRI evidence of brain reorganization during attention and memory tasks in multiple sclerosis. Neuroimage 21(3):858–867
  12. Staffen W et al (2002) Cognitive function and fMRI in patients with multiple sclerosis: evidence for compensatory cortical activation during an attention task. Brain 125(Pt 6):1275–1282
  13. Filippi M et al (2010) The contribution of MRI in assessing cognitive impairment in multiple sclerosis. Neurology 75(23):2121–2128
  14. Jonides J (2004) How does practice make perfect? Nat Neurosci 7:10–11
  15. Morgen K et al (2004) Training-dependent plasticity in patients with multiple sclerosis. Brain 127(Pt 11):2506–2517
  16. Rasova K et al (2005) Is it possible to actively and purposely make use of plasticity and adaptability in the neurorehabilitation treatment of multiple sclerosis patients? A pilot project. Clin Rehabil 19(2):170–181
  17. Poldrack RA et al (1998) The neural basis of visual skill learning: an fMRI study of mirror reading. Cereb Cortex 8(1):1–10
  18. Olesen PJ, Westerberg H, Klingberg T (2004) Increased prefrontal and parietal activity after training of working memory. Nat Neurosci 7(1):75–79
  19. Belleville S et al (2011) Training-related brain plasticity in subjects at risk of developing Alzheimer’s disease. Brain 134:1623–1634
  20. McDonald WI et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 50(1):121–127
  21. Chiaravalloti ND, Balzano J, Moore NB, DeLuca J (2009) The open-trial selective reminding test (OT-SRT) as a tool for the assessment of learning and memory. Clin Neuropsychol 23(2):231–254
  22. Cox RW (1996) AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29(3):162–173
  23. Forman SD et al (1995) Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold. Magn Reson Med 33(5):636–647
  24. McDermott KB et al (1999) Direct comparison of episodic encoding and retrieval of words: an event-related fMRI study. Memory 7(5–6):661–678
  25. Christodoulou C et al (2006) Effects of donepezil on memory and cognition in multiple sclerosis. J Neurol Sci 245:127–136
  26. Krupp LB, Christodoulou C, Melvillle P et al (2004) Donepezil improved memory in multiple sclerosis in a randomized clinical trial. Neurology 63:1579–1585
  27. Lezak MD, Howieson DB, Loring DW (eds) (2004) Neuropsychological assessment, 4th edn. Oxford University Press, New York
  28. Cohen MS et al (1996) Changes in cortical activity during mental rotation. A mapping study using functional MRI. Brain 119(Pt 1):89–100
  29. Formisano E et al (2002) Tracking the mind’s image in the brain I: time-resolved fMRI during visuospatial mental imagery. Neuron 35(1):185–194
  30. Knauff M et al (2000) Cortical activation evoked by visual mental imagery as measured by fMRI. Neuroreport 11(18):3957–3962
  31. Alivisatos BP, Petrides M (1997) Functional activation of the human brain during mental rotation. Neuropsychologia 35:111–118
  32. DeLuca J et al (2008) Neural correlates of cognitive fatigue in multiple sclerosis using functional MRI. J Neurol Sci 270(1–2):28–39
  33. Audoin B et al (2005) Magnetic resonance study of the influence of tissue damage and cortical reorganization on PASAT performance at the earliest stage of multiple sclerosis. Hum Brain Mapp 24(3):216–228
  34. Audoin B et al (2003) Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of MS. Hum Brain Mapp 20(2):51–58
• 作者单位：1. Kessler Foundation Research Center, West Orange, NJ, USA2. Department of Physical Medicine and Rehabilitation, UMDNJ, New Jersey Medical School, Newark, NJ, USA3. Department of Neurology and Neurosciences, UMDNJ, New Jersey Medical School, Newark, NJ, USA4. Neuropsychology and Neuroscience Laboratory, Kessler Foundation Research Center, 300 Executive Drive, Suite 70, West Orange, NJ 07052, USA
• ISSN：1432-1459

文摘

Deficits in new learning and memory are common in persons with multiple sclerosis (MS), though few studies have examined the efficacy of memory retraining in MS. Previous research from our laboratory has demonstrated that the modified Story Memory Technique (mSMT) significantly improves new learning and memory in MS. The present double-blind, placebo-controlled, randomized clinical trial was designed to examine changes in cerebral activation following mSMT treatment. Sixteen individuals with clinically definite MS were randomly assigned to treatment (n = 8) or placebo-control (n = 8) groups, matched for age, education, and disease characteristics. Baseline and follow-up fMRI was collected during performance of learning and memory tasks. No baseline activation differences on fMRI were seen between groups. After treatment, greater activation was evident in the treatment group during performance of a memory task within a widespread cortical network involving frontal, parietal, precuneus, and parahippocampal regions. All participants in the treatment group showed increased activation in frontal and temporal regions in particular. In contrast, the control group showed no significant changes in cerebral activation at follow-up. A significant association was found between increased activation in the right middle frontal gyrus and improved memory performance post-treatment. The increased activation seen likely reflects increased use of strategies taught during treatment when learning new information. This study is the first to demonstrate a significant change in cerebral activation resulting from a behavioral memory intervention in an MS sample. Behavioral interventions can show significant changes in the brain, validating clinical utility.