Activation of AMP-activated protein kinase attenuates hepatocellular carcinoma cell adhesion stimulated by adipokine resistin

详细信息    查看全文

• 作者：Chen-Chieh Yang (38) (39)
  Shun-Fu Chang (40)
  Jian-Kang Chao (41) (42)
  Yi-Liang Lai (43)
  Wei-En Chang (38)
  Wen-Hsiu Hsu (43)
  Wu-Hsien Kuo (38) (43) (44)
  
• 关键词：AMP ; activated protein kinase ; Hepatocellular carcinoma ; Intercellular adhesion molecule ; 1 ; Resistin ; Vascular cell adhesion molecule ; 1
• 刊名：BMC Cancer
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：213 KB
• 参考文献：1. Danese E, Montagnana M, Minicozzi AM, Bonafini S, Ruzzenente O, Gelati M, De Manzoni G, Lippi G, Guidi GC: The role of resistin in colorectal cancer. / Clin Chim Acta 2012, 413:760-. CrossRef
  2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. / CA Cancer J Clin 2011, 61:69-0. CrossRef
  3. Wang SN, Lee KT, Ker CG: Leptin in hepatocellular carcinoma. / World J Gastroenterol 2010, 16:5801-. CrossRef
  4. Lang K, Danchenko N, Gondek K, Shah S, Thompson D: The burden of illness associated with hepatocellular carcinoma in the United States. / J Hepatol 2009, 50:89-9. CrossRef
  5. Calle EE, Kaaks R: Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. / Nat Rev Cancer 2004, 4:579-1. CrossRef
  6. Gunter MJ, Leitzmann MF: Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes. / J Nutr Biochem 2006, 17:145-6. CrossRef
  7. Wieser V, Moschen AR, Tilg H: Adipocytokines and hepatocellular carcinoma. / Dig Dis 2012, 30:508-3. CrossRef
  8. Duan XF, Tang P, Li Q, Yu ZT: Obesity, adipokines and hepatocellular carcinoma. / Int J Cancer 2013, 133:1776-783. CrossRef
  9. Vázquez-Vela ME, Torres N, Tovar AR: White adipose tissue as endocrine organ and its role in obesity. / Arch Med Res 2008, 39:715-8. CrossRef
  10. Dalamaga M, Sotiropoulos G, Karmaniolas K, Pelekanos N, Papadavid E, Lekka A: Serum resistin: a biomarker of breast cancer in postmenopausal women? Association with clinicopathological characteristics, tumor markers, inflammatory and metabolic parameters. / Clin Biochem 2013, 46:584-0. CrossRef
  11. Chen MJ, Yeh YT, Lee KT, Tsai CJ, Lee HH, Wang SN: The promoting effect of adiponectin in hepatocellular carcinoma. / J Surg Oncol 2012, 106:181-. CrossRef
  12. Wai Wong C, Dye DE, Coombe DR: The role of immunoglobulin superfamily cell adhesion molecules in cancer metastasis. / Int J Cell Biol 2012, 2012:340296. CrossRef
  13. Johnson JP: Cell adhesion molecules in the development and progression of malignant melanoma. / Cancer Metastasis Rev 1999, 18:345-7. CrossRef
  14. Yoong KF, McNab G, Hübscher SG, Adams DH: Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma. / J Immunol 1998, 160:3978-8.
  15. Hsu WY, Chao YW, Tsai YL, Lien CC, Chang CF, Deng MC, Ho LT, Kwok CF, Juan CC: Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway. / J Cell Physiol 2011, 226:2181-. CrossRef
  16. Kawanami D, Maemura K, Takeda N, Harada T, Nojiri T, Imai Y, Manabe I, Utsunomiya K, Nagai R: Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. / Biochem Biophys Res Commun 2004, 314:415-. CrossRef
  17. Kim EK, Park JM, Lim S, Choi JW, Kim HS, Seok H, Seo JK, Oh K, Lee DS, Kim KT, Ryu SH, Suh PG: Activation of AMP-activated protein kinase is essential for lysophosphatidic acid-induced cell migration in ovarian cancer cells. / J Biol Chem 2011, 286:24036-5. CrossRef
  18. Hardie DG: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. / Nat Rev Mol Cell Biol 2007, 8:774-5. CrossRef
  19. Hardie DG, Carling D, Carlson M: The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? / Annu Rev Biochem 1998, 67:821-5. CrossRef
  20. Kim HS, Kim MJ, Kim EJ, Yang Y, Lee MS, Lim JS: Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. / Biochem Pharmacol 2012, 83:385-4. CrossRef
  21. Park JJ, Seo SM, Kim EJ, Lee YJ, Ko YG, Ha J, Lee M: Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin β1 signaling. / Biochem Biophys Res Commun 2012, 426:461-. CrossRef
  22. Luo Z, Zhang Y, Li F, He J, Ding H, Yan L, Cheng H: Resistin induces insulin resistance by both AMPK-dependent and AMPK-independent mechanisms in HepG2 cells. / Endocrine 2009, 36:60-. CrossRef
  23. Sands WA, Martin AF, Strong EW, Palmer TM: Specific inhibition of nuclear factor-κB-dependent inflammatory responses by cell type-specific mechanisms upon A2A adenosine receptor gene transfer. / Mol Pharmacol 2004, 66:1147-159. CrossRef
  24. Lee YC, Chen YJ, Wu CC, Lo S, Hou MF, Yuan SS: Resistin expression in breast cancer tissue as a marker of prognosis and hormone therapy stratification. / Gynecol Oncol 2012, 125:742-0. CrossRef
  25. Tung SY, Chang SF, Chou MH, Huang WS, Hsieh YY, Shen CH, Kuo HC, Chen CN: CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1. / J Biomed Sci 2012, 19:91. CrossRef
  26. Kobayashi H, Boelte KC, Lin PC: Endothelial cell adhesion molecules and cancer progression. / Curr Med Chem 2007, 14:377-6. CrossRef
  27. Alexiou D, Karayiannakis AJ, Syrigos KN, Zbar A, Kremmyda A, Bramis I, Tsigris C: Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery. / Eur J Cancer 2001, 37:2392-. CrossRef
  28. Kang X, Wang F, Xie JD, Cao J, Xian PZ: Clinical evaluation of serum concentrations of intercellular adhesion molecule-1 in patients with colorectal cancer. / World J Gastroenterol 2005, 11:4250-.
  29. O'Hanlon DM, Fitzsimons H, Lynch J, Tormey S, Malone C, Given HF: Soluble adhesion molecules (E-selectin, ICAM-1 and VCAM-1) in breast carcinoma. / Eur J Cancer 2002, 38:2252-. CrossRef
  30. Hyodo I, Jinno K, Tanimizu M, Doi T, Nishikawa Y, Hosokawa Y, Moriwaki S: Intercellular adhesion molecule-1 release from human hepatocellular carcinoma. / Cancer Detect Prev 1996, 20:308-5.
  31. Ho JW, Poon RT, Tong CS, Fan ST: Clinical significance of serum vascular cell adhesion molecule-1 levels in patients with hepatocellular carcinoma. / World J Gastroenterol 2004, 10:2014-.
  32. Yusuf-Makagiansar H, Anderson ME, Yakovleva TV, Murray JS, Siahaan TJ: Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases. / Med Res Rev 2002, 22:146-7. CrossRef
  33. Pawelek JM, Chakraborty AK: Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis. / Nat Rev Cancer 2008, 8:377-6. CrossRef
  34. Hardie DG: The AMP-activated protein kinase pathway–new players upstream and downstream. / J Cell Sci 2004, 117:5479-7. CrossRef
  35. Carling D: The AMP-activated protein kinase cascade–a unifying system for energy control. / Trends Biochem Sci 2004, 29:18-4. CrossRef
  36. Kemp BE, Stapleton D, Campbell DJ, Chen ZP, Murthy S, Walter M, Gupta A, Adams JJ, Katsis F, van Denderen B, Jennings IG, Iseli T, Michell BJ, Witters LA: AMP-activated protein kinase, super metabolic regulator. / Biochem Soc Trans 2003, 31:162-. CrossRef
  37. Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T, Walsh K: Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. / J Biol Chem 2004, 279:1304-. CrossRef
  38. Martinelli R, Gegg M, Longbottom R, Adamson P, Turowski P, Greenwood J: ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration. / Mol Biol Cell 2009, 20:995-005. CrossRef
  39. Martin MJ, Carling D, Marais R: Taking the stress out of melanoma. / Cancer Cell 2009, 15:163-. CrossRef
  40. Wang W, Guan KL: AMP-activated protein kinase and cancer. / Acta Physiol (Oxf) 2009, 196:55-3. CrossRef
  41. Zhang BB, Zhou G, Li C: AMPK: an emerging drug target for diabetes and the metabolic syndrome. / Cell Metab 2009, 9:407-6. CrossRef
  42. Taliaferro-Smith L, Nagalingam A, Zhong D, Zhou W, Saxena NK, Sharma D: LKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cells. / Oncogene 2009, 28:2621-3. CrossRef
  43. The pre-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2407/14/112/prepub
  
• 作者单位：Chen-Chieh Yang (38) (39)
  Shun-Fu Chang (40)
  Jian-Kang Chao (41) (42)
  Yi-Liang Lai (43)
  Wei-En Chang (38)
  Wen-Hsiu Hsu (43)
  Wu-Hsien Kuo (38) (43) (44)
  
  38. Division of Gastroenterology, Department of Internal Medicine, Armed-Forces Hualien General Hospital, Hualien, 97144, Taiwan
  39. Mennonite Christian Hospital, Hualien, 97059, Taiwan
  40. Biophotonics & Molecular Imaging Research Center, National Yang Ming University, Taipei, 11221, Taiwan
  41. Department of Psychiatry, Taipei Veterans General Hospital, Yuli branch, Hualien, 98142, Taiwan
  42. Department of Health Administration, Tuz Chi College of Technology, Hualien, Taiwan
  43. Division of Gastroenterology, Department of Internal Medicine, Armed-Forces Taichung General Hospital, Taiping District, Taichung City, 41168, Taiwan
  44. School of Medicine, National Defense Medical Center, Taipei, 11490, Taiwan
  
• ISSN：1471-2407

文摘

Background Resistin, adipocyte-secreting adipokine, may play critical role in modulating cancer pathogenesis. The aim of this study was to investigate the effects of resistin on HCC adhesion to the endothelium, and the mechanism underlying these resistin effects. Methods Human SK-Hep1 cells were used to study the effect of resistin on intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) expressions as well as NF-κB activation, and hence cell adhesion to human umbilical vein endothelial cells (HUVECs). 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, was used to determine the regulatory role of AMPK on HCC adhesion to the endothelium in regard to the resistin effects. Results Treatment with resistin increased the adhesion of SK-Hep1 cells to HUVECs and concomitantly induced NF-κB activation, as well as ICAM-1 and VCAM-1 expressions in SK-Hep1 cells. Using specific blocking antibodies and siRNAs, we found that resistin-induced SK-Hep1 cell adhesion to HUVECs was through NF-κB-regulated ICAM-1 and VCAM-1 expressions. Moreover, treatment with AICAR demonstrated that AMPK activation in SK-Hep1 cells significantly attenuates the resistin effect on SK-Hep1 cell adhesion to HUVECs. Conclusions These results clarify the role of resistin in inducing HCC adhesion to the endothelium and demonstrate the inhibitory effect of AMPK activation under the resistin stimulation. Our findings provide a notion that resistin play an important role to promote HCC metastasis and implicate AMPK may be a therapeutic target to against HCC metastasis.