参考文献:1. Linand CC, Anseth KS. PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharm Res. 2009;26:631-3. CrossRef 2. Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K. The development of microgels/nanogels for drug delivery applications. Prog Polym Sci. 2008;33:448-7. CrossRef 3. Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm. 2000;50:27-6. CrossRef 4. Peppas NA, Hilt JZ, Khademhosseini A, Langer R. Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv Mater. 2006;18:1345-0. CrossRef 5. Sawhney AS, Pathak CP, Hubbell JA. Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(alpha-hydroxy acid) diacrylate macromers. Macromolecules. 1993;26:581-. CrossRef 6. Westand JL, Hubbell JA. Photopolymerized hydrogel materials for drug-delivery applications. React Polym. 1995;25:139-7. CrossRef 7. Kloudaand L, Mikos AG. Thermo-responsive hydrogels in biomedical applications. Eur J Pharm Biopharm. 2008;68:34-5. CrossRef 8. Ruel-Gariepyand E, Leroux JC. In situ-forming hydrogels—review of temperature-sensitive systems. Eur J Pharm Biopharm. 2004;58:409-6. CrossRef 9. Jeong B, Kim SW, Bae YH. Thermosensitive sol–gel reversible hydrogels. Adv Drug Deliv Rev. 2002;54:37-1. CrossRef 10. Hoffman AS. Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics. J Control Release. 1987;6:297-05. CrossRef 11. Donati G. Emerging therapies for neovascular age-related macular degeneration: state of the art. Ophthalmologica. 2007;221:366-7. CrossRef 12. Fung AE, Lalwani GA, Rosenfeld PJ, Dubovy SR, Michels S, Feuer WJ, / et al. An optical coherence tomography-guided, variable dosing regimen with intravitreal ranibizumab (lucentis) for neovascular age-related macular degeneration. Am J Ophthalmol. 2007;143:566-3. CrossRef 13. Rosenfeld PJ. Intravitreal Avastin: the low cost alternative to lucentis? Am J Ophthalmol. 2006;142:141-. CrossRef 14. Bhatnagar P, Spaide Richard F, Takahashi Beatriz S, Peragallo Jason H, Freund KB, Klancnik James Jr M, / et al. Ranibizumab for treatment of choroidal neovascularization secondary to age-related macular degeneration. Retina. 2007;27:846-0. CrossRef 15. Turturro SB, Guthrie MJ, Appel AA, Drapala PW, Brey EM, Pérez-Luna VH, / et al. The effects of cross-linked thermo-responsive PNIPAAm-based hydrogel injection on retinal function. Biomaterials. 2011;32:3620-. CrossRef 16. Mari M, Morales A, Colell A, Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal. 2009;11:2685-00. CrossRef 17. Bertrand N, Fleischer JG, Wasan KM, Leroux J-C. Pharmacokinetics and biodistribution of N-isopropylacrylamide copolymers for the design of pH-sensitive liposomes. Biomaterials. 2009;30:2598-05. CrossRef 18. Chiu Y-C, Larson JC, Perez-Luna VH, Brey EM. Formation of microchannels in poly(ethylene glycol) hydrogels by selective degradation of patterned microstructures. Chem Mater. 2009;21:1677-2. CrossRef 19. Drapala PW, Brey EM, Mieler WF, Venerus DC, Derwent JJK, Pérez-Luna VH. Role of thermo-responsiveness and poly(ethylene glycol) diacrylate cross-link density on protein release from poly(N-isopropylacrylamide) hydrogels. J Biomater Sci Polym Ed. 2011;22:59-5. CrossRef 20. Schild HG. Poly (N-isopropylacrylamide) - experiment, theory and application. Prog Polym Sci. 1992;17:163-49. CrossRef 21. Kaneko Y, Nakamura S, Sakai K, Aoyagi T, Kikuchi A, Sakurai Y, / et al. Rapid deswelling response of poly(N-isopropylacrylamide) hydrogels by the formation of water release channels using poly(ethylene oxide) graft chains. Macromolecules. 1998;31:6099-05. CrossRef 22. Costa R, Carneiro A, Rocha A, Pirraco A, Falcao M, Vasques L, / et al. Bevacizumab and ranibizumab on microvascular endothelial cells: a comparative study. J Cell Biochem. 2009;108:1410-. CrossRef 23. Klettnerand A, Roider J. Comparison of bevacizumab, ranibizumab, and pegaptanib in vitro: efficiency and possible additional pathways. Investig Ophthalmol Vis Sci. 2008;49:4523-. CrossRef 24. Kricheldorf HR, Nuyken O, Swift G. Handbook of polymer synthesis. New York: Marcel Dekker; 2005. 25. Flory PJ. Principles of polymer chemistry. Ithaca: Cornell University Press; 1953. 26. Mason MN, Metters AT, Bowman CN, Anseth KS. Predicting controlled-release behavior of degradable PLA-b-PEG-b-PLA hydrogels. Macromolecules. 2001;34:4630-. CrossRef 27. Linand CC, Metters AT. Hydrogels in controlled release formulations: network design and mathematical modeling. Adv Drug Deliv Rev. 2006;58:1379-08. CrossRef 28. Nolan CM, Reyes CD, Debord JD, Garcia AJ, Lyon LA. Phase transition behavior, protein adsorption, and cell adhesion resistance of poly(ethylene glycol) cross-linked microgel particles. Biomacromolecules. 2005;6:2032-. CrossRef 29. Furyk S, Zhang YJ, Ortiz-Acosta D, Cremer PS, Bergbreiter DE. Effects of end group polarity and molecular weight on the lower critical solution temperature of poly(N-isopropylacrylamide). J Polym Sci A Polym Chem. 2006;44:1492-01. CrossRef 30. Friedman M. Chemistry, biochemistry, and safety of acrylamide. A review. J Agric Food Chem. 2003;51:4504-6. CrossRef 31. Williams CG, Malik AN, Kim TK, Manson PN, Elisseeff JH. Variable cytocompatibility of six cell lines with photoinitiators used for polymerizing hydrogels and cell encapsulation. Biomaterials. 2005;26:1211-. CrossRef 32. Yamaoka T, Tabata Y, Ikada Y. Distribution and tissue uptake of poly(ethylene glycol) with different molecular-weights after intravenous administration to mice. J Pharm Sci. 1994;83:601-. CrossRef 33. Metters AT, Anseth KS, Bowman CN. A statistical kinetic model for the bulk degradation of PLA-b-PEG-b-PLA hydrogel networks: incorporating network non-idealities. J Phys Chem B. 2001;105:8069-6. CrossRef 34. Metters AT, Anseth KS, Bowman CN. Fundamental studies of a novel, biodegradable PEG-b-PLA hydrogel. Polymer. 2000;41:3993-004. CrossRef 35. Metters AT, Bowman CN, Anseth KS. A statistical kinetic model for the bulk degradation of PLA-b-PEG-b-PLA hydrogel networks. J Phys Chem B. 2000;104:7043-. CrossRef 36. Fipulaand D, Zhao H. Releasable PEGylation of proteins with customized linkers. Adv Drug Deliv Rev. 2008;60:29-9. CrossRef
作者单位:Pawel W. Drapala (1) Bin Jiang (2) Yu-Chieh Chiu (2) William F. Mieler (4) Eric M. Brey (2) (3) Jennifer J. Kang-Mieler (2) Victor H. Pérez-Luna (1)
1. Department of Chemical and Biological Engineering, Illinois Institute of Technology, 10 West 33rd Street, Chicago, Illinois, 60616-3793, USA 2. Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA 4. Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA 3. Department of Research, Hines V.A. Hospital, Hines, Illinois, USA