Evaluation of transcatheter arterial embolization therapy on hepatocellular carcinomas using contrast-enhanced harmonic power Doppler sonography: comparison with CT, power Doppler sonography, and dynamic MRI

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• 作者：Toshihide Shima (A1)
  Masayuki Mizuno (A1)
  Hideaki Otsuji (A2)
  Chiemi Mizuno (A1)
  Hirozumi Obata (A1)
  Hyohun Park (A1)
  Shinobu Nakajo (A1)
  Takeshi Okanoue (A3)
  
• 关键词：therapeutic effect ; transcatheter arterial embolization ; hepatocellular carcinoma ; contrast ; enhanced harmonic power Doppler sonography ; dynamic MRI
• 刊名：Journal of Medical Ultrasonics
• 出版年：2005
• 出版时间：September 2005
• 年：2005
• 卷：32
• 期：3
• 页码：107-113
• 全文大小：478KB
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• 作者单位：Toshihide Shima (A1)
  Masayuki Mizuno (A1)
  Hideaki Otsuji (A2)
  Chiemi Mizuno (A1)
  Hirozumi Obata (A1)
  Hyohun Park (A1)
  Shinobu Nakajo (A1)
  Takeshi Okanoue (A3)
  
  A1. Departments of Gastroenterology and Hepatology, Saiseikai Suita Hospital, 1-2 Kawazono-cho, Suita, Osaka, 564-0013, Japan
  A2. Department of Radiology, Saiseikai Suita Hospital, Osaka, Japan
  A3. Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
  

文摘

Purpose The aim of this study was to assess and compare the sensitivity of power Doppler sonography, contrast-enhanced sonography, plain computed tomography (CT), and dynamic magnetic resonance imaging (MRI) for detecting hepatocellular carcinoma (HCC) nodules incompletely treated with transcatheter arterial embolization (TAE). Methods A total of 63 unresectable HCC nodules were examined in this study. The HCCs were treated with TAE. All patients underwent plain CT, power Doppler sonography, contrast-enhanced harmonic power Doppler sonography, and dynamic MRI 1 week after TAE. The sensitivity of each modality to incompletely treated HCC nodules was compared. Detection of the residual viable HCC on angiography or tumor biopsy was regarded as the gold standard for the diagnosis of incomplete treatment. Results Twenty-four nodules (38%) were diagnosed as incompletely treated. The sensitivities of plain CT, power Doppler sonography, contrast-enhanced harmonic power Doppler sonography, and dynamic MRI to these incompletely treated nodules were 42% (10/24), 46% (11/24), 88% (21/24), and 79% (19/24), respectively. Eighty percent (19 nodules) of the 24 incompletely treated nodules were located within a depth of less than 8?cm. The sensitivities of plain CT, power Doppler sonography, contrast-enhanced harmonic power Doppler sonography, and dynamic MRI to these superficial incompletely treated nodules were 37% (7/19), 53% (10/19), 100% (19/19), and 74% (14/19), respectively. In contrast, the sensitivities of each modality to deeply located nodules were 60% (3/5), 20% (1/5), 40% (2/5), and 100% (5/5), respectively. Conclusion Plain CT and power Doppler sonography had a low sensitivity to HCC nodules incompletely treated with TAE. Except for those that were deeply located, contrast-enhanced harmonic sonography showed the highest sensitivity in detecting incompletely treated HCC nodules.