Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma

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• 作者：Tai-Lin Huang (13) (14)
  Hsuan-Chih Hsu (11)
  Hui-Chun Chen (11)
  Hsin-Ching Lin (12)
  Chih-Yen Chien (12)
  Fu-Min Fang (11)
  Chih-Cheng Huang (13)
  Hsueh-Wen Chang (14)
  Wen-Neng Chang (13)
  Chi-Ren Huang (13)
  Nai-Wen Tsai (13)
  Chia-Te Kung (11)
  Hung-Chen Wang (12)
  Wei-Che Lin (13)
  Ben-Chung Cheng (14) (14)
  Yu-Jih Su (14) (14)
  Ya-Ting Chang (13) (14)
  Chuang-Rung Chang (14)
  Teng-Yeow Tan (13)
  Cheng-Hsien Lu (13) (14)
  
• 关键词：Atherosclerosis ; Nasopharyngeal carcinoma ; Radiotherapy ; Risk factors
• 刊名：Radiation Oncology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：8
• 期：1
• 全文大小：193 KB
• 参考文献：1. Chan AT, Grégoire V, Lefebvre JL, Licitra L, Felip E, EHNS-ESMO-ESTRO Guidelines Working Group: Nasopharyngeal cancer: EHNS-ESMO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up. / Ann Oncol 2010,21(5):v187-v189. CrossRef
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• 作者单位：Tai-Lin Huang (13) (14)
  Hsuan-Chih Hsu (11)
  Hui-Chun Chen (11)
  Hsin-Ching Lin (12)
  Chih-Yen Chien (12)
  Fu-Min Fang (11)
  Chih-Cheng Huang (13)
  Hsueh-Wen Chang (14)
  Wen-Neng Chang (13)
  Chi-Ren Huang (13)
  Nai-Wen Tsai (13)
  Chia-Te Kung (11)
  Hung-Chen Wang (12)
  Wei-Che Lin (13)
  Ben-Chung Cheng (14) (14)
  Yu-Jih Su (14) (14)
  Ya-Ting Chang (13) (14)
  Chuang-Rung Chang (14)
  Teng-Yeow Tan (13)
  Cheng-Hsien Lu (13) (14)
  
  13. Department of Radiology, National Sun Yat-Sen University, Kaohsiung, Taiwan
  14. Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
  11. Department of Emergency Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan
  12. Department of Neurosurgery, National Sun Yat-Sen University, Kaohsiung, Taiwan
  
• ISSN：1748-717X

文摘

Background Vascular abnormalities are the predominant histologic changes associated with radiation in nasopharyngeal carcinoma (NPC). This study examined if the duration after radiotherapy correlates with the progression of carotid intima-media thickness (IMT) and investigated its relationship with inflammatory markers. Methods One hundred and five NPC patients post-radiotherapy for more than one year and 25 healthy control subjects were examined by B-mode ultrasound for IMT measurement at the far wall of the common carotid artery (CCA). Surrogate markers including lipid profile, HbA1c, and high sensitive C-reactive protein (hs-CRP) were assessed. Results The IMT of CCA was significantly increased in NPC patients and carotid plaque was detected in 38 NPC patients (38/105, 36.2%). Significant risk factors for carotid plaques included age, duration after radiotherapy, and HbA1c levels. Age, duration after radiotherapy, hs-CRP, HbA1c, and platelet count positively correlated with IMT. The cut-off value of age and duration after radiotherapy for the presence of plaque was 52.5?years and 42.5?months, respectively. In NPC subjects, multiple linear regression analysis revealed that age, gender, duration after radiotherapy and platelet counts were independently associated with CCA IMT. After adjustments for age, gender and platelet counts, IMT increased in a linear manner with duration after radiotherapy. Conclusions Radiation-induced vasculopathy is a dynamic and progressive process due to late radiation effects. Extra-cranial color-coded duplex sonography can be part of routine follow-up in NPC patients aged ?0?years at 40?months post-radiotherapy.