Impact of chemotherapy-related prognostic factors on long-term survival in patients with stage III colorectal cancer after curative resection
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- 作者：Wen-Sy Tsai (1) (2)
Pao-Shiu Hsieh (1) (2)
Chien-Yuh Yeh (1) (2)
Jy-Ming Chiang (1) (2)
Reiping Tang (1) (2)
Jinn-Shiun Chen (1) (2)
Chung Rong Changchien (1) (2)
Jeng Yi Wang (1) (2) - 关键词：Colorectal cancer ; Adjuvant chemotherapy ; Prognosis
- 刊名：International Journal of Clinical Oncology
- 出版年：2013
- 出版时间：April 2013
- 年：2013
- 卷：18
- 期：2
- 页码：242-253
- 全文大小：353 KB
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Pao-Shiu Hsieh (1) (2)
Chien-Yuh Yeh (1) (2)
Jy-Ming Chiang (1) (2)
Reiping Tang (1) (2)
Jinn-Shiun Chen (1) (2)
Chung Rong Changchien (1) (2)
Jeng Yi Wang (1) (2)
1. Division of Colon and Rectal Surgery, Chang Gung Memorial Hospital, 5 Fu-Hsing St., Kueishan, Taoyuan, 333, Taiwan
2. Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan - ISSN：1437-7772
文摘
Background This retrospective study evaluated the prognostic factors of chemotherapy in stage III colorectal cancer after curative resection. Methods From 1996 to 2001, 1,054 patients with primary single colorectal cancer underwent curative resection. Seven hundred sixteen patients received various 5-fluorouracil (FU)-based adjuvant chemotherapy regimens, including oral and intravenous treatments. The chemotherapy-related parameters examined included therapeutic duration, frequency, route of administration, composition of combination therapies, and postoperative time interval from the operation to the start of chemotherapy. Results The therapeutic duration and postoperative time interval of starting therapy were independent prognostic factors, in addition to clinicopathological factors. The 8-year cancer-specific/overall survival rates in patients who received chemotherapy for >4?months (63.0/58.6%) were significantly higher than the rates in patients who received no chemotherapy (56.7/37.7%, P?<?0.01) and those who remained on chemotherapy for 1-?months (49.4/41.9%, P?<?0.05). The 8-year cancer-specific/overall survival rates in patients who waited 1-?weeks after surgery to receive chemotherapy (62.9/58.5%) were significantly higher versus rates in those who did not receive chemotherapy (56.7/37.7%) and those who did not receive chemotherapy until >5?weeks after surgery (52.3/45.9%) (both P?<?0.05). Survival rates did not differ between patients who did not undergo chemotherapy, those for whom chemotherapy lasted 1-?months, and patients who did not receive chemotherapy until >5?weeks after surgery. Conclusions The appropriate duration of therapy and early chemotherapy after surgery were 2 of the most important factors in eradicating occult cancer and effecting long-term survival benefits in patients with stage III colorectal cancer.