Aminosilane as an effective binder for hydroxyapatite-gelatin nanocomposites
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- 作者：Tzy-Jiun M. Luo ; Ching-Chang Ko ; Chi-Kai Chiu ; Jacob Llyod and Uk Huh
- 关键词：Aminosilane ; Hydroxyapatite ; Nanocomposite ; Osteoblast ; Biomaterials
- 刊名：Journal of Sol-Gel Science and Technology
- 出版年：2010
- 出版时间：February, 2010
- 年：2010
- 卷：53
- 期：2
- 页码：459-465
- 全文大小：516.3 KB
文摘
Aminosilane has been explored as an alternative chemical linker to facilitate the binding and solidification of hydroxyapatite-gelatin nanocomposite at room temperature, which was synthesized using co-precipitation method in the presence of gelatin. This aminosilane treatment was found effective at low concentration (~25 μL/mL) and the solidification and dehydration of hydroxyapatite-gelatin slurry completes within hours depending on the amount of aminosilane. The resulting sample exhibits compressive strength of 133 MPa, about 40 % higher than glutaraldehyde treated samples, and shows good biocompatibility based on cell adhesion, proliferation, alkaline phosphate synthesis, and mineralization studies.