A pilot study of bevacizumab combined with etoposide and cisplatin in breast cancer patients with leptomeningeal carcinomatosis
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- 作者：Pei-Fang Wu ; Ching-Hung Lin ; Ching-Hua Kuo ; Wei-Wu Chen ; Dah-Cherng Yeh…
- 关键词：Leptomeningeal carcinomatosis ; Bevacizumab ; Vascular endothelial growth factor (VEGF) ; Anti ; angiogenic therapy ; Anti ; VEGF therapy
- 刊名：BMC Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：516 KB
- 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background Elevated vascular endothelial growth factor (VEGF) was associated with poor prognosis in leptomeningeal carcinomatosis and anti-angiogenic therapy was found to prolong the survival of mice in preclinical studies. This prospective pilot study investigated the efficacy of anti-VEGF therapy plus chemotherapy in patients with leptomeningeal carcinomatosis originating from breast cancer.