Toward numerical simulations of fluid–structure interactions for investigation of obstructive sleep apnea

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• 作者：Chien-Jung Huang ; Shao-Ching Huang…
• 关键词：Fluid–structure interaction ; Immersed boundary method ; Biomedical flows
• 刊名：Theoretical and Computational Fluid Dynamics
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：30
• 期：1-2
• 页码：87-104
• 全文大小：1,996 KB
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• 作者单位：Chien-Jung Huang (1)
  Shao-Ching Huang (2)
  Susan M. White (3)
  Sanjay M. Mallya (3)
  Jeff D. Eldredge (1)
  
  1. Mechanical and Aerospace Engineering, University of California, Los Angeles, 420 Westwood Plaza, Los Angeles, CA, 90095-1597, USA
  2. UCLA Institute for Digital Research and Education, Los Angeles, CA, USA
  3. Oral and Maxillofacial Radiology, UCLA School of Dentistry, Los Angeles, CA, USA
  
• 刊物类别：Physics and Astronomy
• 刊物主题：Physics
  Fluids
  Mathematical and Computational Physics
  Engineering Fluid Dynamics
  Computational Science and Engineering
  Thermodynamics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2250

文摘

Obstructive sleep apnea (OSA) is a medical condition characterized by repetitive partial or complete occlusion of the airway during sleep. The soft tissues in the airway of OSA patients are prone to collapse under the low-pressure loads incurred during breathing. This paper describes efforts toward the development of a numerical tool for simulation of air–tissue interactions in the upper airway of patients with sleep apnea. A procedure by which patient-specific airway geometries are segmented and processed from dental cone-beam CT scans into signed distance fields is presented. A sharp-interface embedded boundary method based on the signed distance field is used on Cartesian grids for resolving the airflow in the airway geometries. For simulation of structure mechanics with large expected displacements, a cut-cell finite element method with nonlinear Green strains is used. The fluid and structure solvers are strongly coupled with a partitioned iterative algorithm. Preliminary results are shown for flow simulation inside the three-dimensional rigid upper airway of patients with obstructive sleep apnea. Two validation cases for the fluid–structure coupling problem are also presented.