Controlled hydrophobic/hydrophilic chitosan: colloidal phenomena and nanosphere formation

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• 作者：Rangrong Yoksan ; Michiya Matsusaki ; Mitsuru Akashi and Suwabun Chirachanchai
• 关键词：Chitosan nanospheres ; Homogeneous reaction ; N ; Phthaloylchitosan ; grafted poly(ethylene glycol) methyl ether ; Self ; aggregation ; Colloidal phenomena
• 刊名：Colloid & Polymer Science
• 出版年：2004
• 出版时间：February 2004
• 年：2004
• 卷：282
• 期：4
• 页码：337-342
• 全文大小：392 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Physical Chemistry
  Soft Matter and Complex Fluids
  Characterization and Evaluation Materials
  Food Science
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-1536

文摘

N-Phthaloylchitosan-grafted poly(ethylene glycol) methyl ether (mPEG) gives a milky solution when dispersed in water and a series of solvents. The appearance of turbidity depends on the types of solvents, i.e., protic and aprotic solvents. N-Phthaloylchitosan-grafted mPEG shows an aggregation of sphere-like particles as observed by scanning electron microscopy. Transmission electron microscopy indicates that the spheres are at the nano level. When the chain length of mPEG is as high as 5×103 Da the sphere size becomes as small as 80–100 nm on average as observed by transmission electron microscopy. By simply adjusting the hydrophobicity/hydrophilicity of the chitosan chain, a stable nanosphere can be obtained directly.