Depressive-Like Behaviors in a Rat Model of Chronic Cerebral Hypoperfusion

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• 作者：Sang Rim Lee ; Boryoung Choi ; Saswati Paul ; Ju-Ha Seo…
• 关键词：Chronic cerebral hypoperfusion ; Vascular depression ; Hypothalamus ; pituitary ; adrenal axis ; Glucocorticoid receptor ; Rat model
• 刊名：Translational Stroke Research
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：6
• 期：3
• 页码：207-214
• 全文大小：333 KB
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• 作者单位：Sang Rim Lee (1) (2)
  Boryoung Choi (1) (2)
  Saswati Paul (2)
  Ju-Ha Seo (1)
  Dong Bin Back (1)
  Jung-Soo Han (2)
  Dong-Hee Choi (3)
  Kyoung Ja Kwon (1)
  Chan Young Shin (4)
  Jongmin Lee (5)
  Seol-Heui Han (1)
  Hahn Young Kim (1)
  
  1. Department of Neurology, Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, Research Institute of Medical Science, School of Medicine, Konkuk University, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, 143-729, Republic of Korea
  2. Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea
  3. Department of Medicine, Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, School of Medicine, Konkuk University, Seoul, Republic of Korea
  4. Department of Pharmacology, Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, School of Medicine, Konkuk University, Seoul, Republic of Korea
  5. Department of Rehabilitation Medicine, Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, School of Medicine, Konkuk University, Seoul, Republic of Korea
  
• 刊物主题：Neurosciences; Neurology; Cardiology; Neurosurgery; Vascular Surgery;
• 出版者：Springer US
• ISSN：1868-601X

文摘

The vascular depression hypothesis suggests that there is an association between cerebrovascular pathophysiology and depression in the elderly. We investigated depressive-like behaviors and perturbations in the hypothalamus-pituitary-adrenal (HPA) axis in a rat model of chronic cerebral hypoperfusion. We modeled chronic cerebral hypoperfusion by permanent occlusion of the bilateral common carotid arteries (BCCAo) in Wistar rats. Sucrose preference, forced swim, and social interaction tests were performed to measure depressive-like behaviors. The plasma levels of adrenocorticotropic hormone and corticosterone, and the hippocampal expression of the glucocorticoid receptor (GR) were assessed. Sucrose preference (P--.045) and social withdrawal (P--.038) were significantly enhanced in BCCAo rats. Increased plasma levels of corticosterone (P--.034) and impaired cytosolic-to-nuclear translocation of the GR protein were observed in the hippocampus (P--.038) of BCCAo rats. Our experimental results support the clinical hypothesis that vascular depression can be induced by chronic cerebral hypoperfusion. Increased HPA axis activity and perturbation of the GR signaling pathway in the hippocampus may be associated with depressive-like behaviors in rats with chronic cerebral hypoperfusion.