Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage

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• 作者：Tingrong Liu ; Chen Li ; Haige Sun ; Tiantian Luo ; Ying Tan ; Di Tian…
• 关键词：Curcumin ; c ; Jun N ; terminal kinase ; Monocyte chemoattractant protein ; 1 ; Cholesterol efflux ; Macrophages
• 刊名：Inflammation Research
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：63
• 期：10
• 页码：841-850
• 全文大小：1,617 KB
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• 作者单位：Tingrong Liu (1)
  Chen Li (1)
  Haige Sun (1)
  Tiantian Luo (1)
  Ying Tan (1)
  Di Tian (1)
  Zhigang Guo (1)
  
  1. Department of Cardiology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, People’s Republic of China
  
• ISSN：1420-908X

文摘

Objective To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved. Methods The macrophages were treated with ox-LDL and various concentrations of curcumin simultaneously. The MCP-1 expression was measured by enzyme-linked immunosorbent assay. The apoAI-mediated cholesterol efflux was measured by 3H-cholesterol-labeled counting radioactivity. The activation of intracellular signaling pathways was studied by Western blotting. Results Curcumin decreased the production of MCP-1 induced by ox-LDL in macrophages. MCP-1 expression was restrained by the inhibition of c-Jun N-terminal kinase (JNK) pathway (SP600125) and NF-κB pathway (BAY11-7082). Curcumin suppressed the phosphorylation of JNK and activation of NF-κB. Curcumin also enhanced RCT via up-regulating the expression of liver X receptor alpha (LXRα), ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI). Additionally, the inhibition of JNK (SP600125) increased cholesterol efflux and increased the expression of ABCA1 and SR-BI, but had no effect on LXRα. Conclusion Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-κB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR–ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis.