HDL Cholesterol Efflux Capacity: Cardiovascular Risk Factor and Potential Therapeutic Target
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  • 作者：Anish Bhatt ; Anand Rohatgi
  • 关键词：HDL ; Cholesterol efflux ; Reverse cholesterol transport ; Atherosclerosis ; Cardiovascular
  • 刊名：Current Atherosclerosis Reports
  • 出版年：2016
  • 出版时间：January 2016
  • 年：2016
  • 卷：18
  • 期：1
  • 全文大小：449 KB
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  • 作者单位：Anish Bhatt (1)
    Anand Rohatgi (1)

    1. Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-8830, USA
  • 刊物主题：Angiology; Cardiology;
  • 出版者：Springer US
  • ISSN：1534-6242
    • 文摘
    Low high-density lipoprotein cholesterol (HDL-C) levels are associated with incident cardiovascular events; however, many therapies targeting increases in HDL-C have failed to show consistent clinical benefit. Thus, focus has recently shifted toward measuring high-density lipoprotein (HDL) function. HDL is the key mediator of reverse cholesterol transport, the process of cholesterol extraction from foam cells, and eventual excretion into the biliary system. Cholesterol efflux from peripheral macrophages to HDL particles has been associated with atherosclerosis in both animals and humans. We review the mechanism of cholesterol efflux and the emerging evidence on the association between cholesterol efflux capacity and cardiovascular disease in human studies. We also focus on the completed and ongoing trials of novel therapies targeting different aspects of HDL cholesterol efflux.

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