Facilitated c-Fos Induction in Mice Deficient for the AMPA Receptor-Associated Protein Ckamp44

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• 作者：Boyi Yang ; Christof Dormann ; Miriam A. Vogt…
• 刊名：Cellular and Molecular Neurobiology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：36
• 期：7
• 页码：1215-1218
• 全文大小：620 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Animal Anatomy, Morphology and Histology
  
• 出版者：Springer Netherlands
• ISSN：1573-6830
• 卷排序：36

文摘

The recently identified Cystine-knot containing AMPAR-associated protein (Ckamp44) represents a novel AMPAR-related protein that critically controls AMPAR-mediated currents and short-term plasticity. However, the effects of the lack of this protein at network level are not entirely understood. Here we used c-Fos brain mapping to analyse whether the excitatory/inhibitory balance is altered in the absence of the Ckamp44. We found that Ckamp44−/− mice treated with an NMDAR antagonist exhibited a very robust c-Fos expression pattern, similar with that seen in mice lacking the GluN2A subunit of NMDAR treated with the same compound. This finding is unexpected, in particular, since Ckamp44 expression is strongest in dentate gyrus granule cells and less abundant in the rest of the brain.Keywordsc-FosCkamp44 (Shisa9)AMPA receptorsNMDA receptors