Hepatitis C prevalence in Denmark -an estimate based on multiple national registers

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• 作者：Peer Brehm Christensen (1)
  Gordon Hay (2)
  Peter Jepsen (3)
  Lars Haukali Omland (4)
  S?ren Andreas Just (5)
  Henrik Bygum Krarup (6)
  Nina Weis (7)
  Niels Obel (4)
  Susan Cowan (8)
  
• 刊名：BMC Infectious Diseases
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：12
• 期：1
• 全文大小：198KB
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  31. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/12/178/prepub
  
• 作者单位：Peer Brehm Christensen (1)
  Gordon Hay (2)
  Peter Jepsen (3)
  Lars Haukali Omland (4)
  S?ren Andreas Just (5)
  Henrik Bygum Krarup (6)
  Nina Weis (7)
  Niels Obel (4)
  Susan Cowan (8)
  
  1. Department of Infectious Diseases, Odense University Hospital, Building 1, 2 floor, Penthouse block 6, Sdr Boulevard, Odense C, 29 5000, Denmark
  2. School of Social and Political Sciences, University of Glasgow, Scotland, UK
  3. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
  4. Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark
  5. Department of Medicine, Svendborg Hospital, Svendborg, Denmark
  6. Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
  7. Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Denmark
  8. Department of Epidemiology, Statens Serum Institute, Copenhagen, Denmark
  

文摘

Background A national survey for chronic hepatitis C has not been performed in Denmark and the prevalence is unknown. Our aim was to estimate the prevalence of chronic hepatitis C from public registers and the proportion of these patients who received specialized healthcare. Methods Patients with a diagnosis of chronic hepatitis C were identified from four national registers: a laboratory register, the Hospital Discharge Register, a clinical database of chronic viral hepatitis and the Register of Communicable Diseases. The total population diagnosed with hepatitis C was estimated by capture-recapture analysis. The population with undiagnosed hepatitis C was derived from the national register of drug users by comparing diagnosed and tested persons. Results A total of 6,935 patients diagnosed with chronic hepatitis C were identified in the four registers and the estimated population diagnosed with the disease was 9,166 persons (95%?C.I. interval 8,973 -9,877), corresponding to 0.21% (95% CI 0.21%-0.23%) of the Danish population over 15years of age. The prevalence was highest among persons 40-9years old (0.39%) and males (0.28%). It was estimated that 40% of the diagnosed patients lived in the capital region, and 33.5% had attended specialised healthcare. It was estimated that 46% of hepatitis C patients had not been diagnosed and the total population with chronic hepatitis C in Denmark was 16,888 (95%?C.I. 16,474-18,287), corresponding to 0.38% (95% CI 0.37-0.42) of the population over 15years of age. Conclusions The estimated prevalence of chronic hepatitis C in Denmark was 0.38%. Less than half of the patients with chronic hepatitis C in Denmark have been identified and among these patients, one in three has attended specialised care.