A family history of breast cancer will not predict female early onset breast cancer in a population-based setting

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• 作者：Geertruida H de Bock (1) (2)
  Catharina E Jacobi (2)
  Caroline Seynaeve (3)
  Elly MM Krol-Warmerdam (4)
  Jannet Blom (3)
  Christi J van Asperen (5)
  Cees J Cornelisse (6)
  Jan GM Klijn (3)
  Peter Devilee (7)
  Rob AEM Tollenaar (4)
  Cecile TM Brekelmans (3)
  Johannes C van Houwelingen (8)
  
• 刊名：BMC Cancer
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：8
• 期：1
• 全文大小：533KB
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  26. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/8/203/prepub
  
• 作者单位：Geertruida H de Bock (1) (2)
  Catharina E Jacobi (2)
  Caroline Seynaeve (3)
  Elly MM Krol-Warmerdam (4)
  Jannet Blom (3)
  Christi J van Asperen (5)
  Cees J Cornelisse (6)
  Jan GM Klijn (3)
  Peter Devilee (7)
  Rob AEM Tollenaar (4)
  Cecile TM Brekelmans (3)
  Johannes C van Houwelingen (8)
  
  1. Department of Epidemiology, Groningen University Medical Center, Groningen, The Netherlands
  2. Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
  3. Department of Medical Oncology, Erasmus Medical Center-Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
  4. Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
  5. Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
  6. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
  7. Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
  8. Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands
  
• ISSN：1471-2407

文摘

Background An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting. Methods An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer. Results The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12-0.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83-.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33-.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30. Conclusion Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.