Life-long endurance running is associated with reduced glycation and mechanical stress in connective tissue

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作者：Christian Couppé (1) (2) René B. Svensson (1) Jean-Francois Grosset (3) (4) Vuokko Kovanen (5) Rie H. Nielsen (1) Morten R. Olsen (1) Jytte O. Larsen (6) Stephan F. E. Praet (7) Dorthe Skovgaard (1) (8) Mette Hansen (1) (9) Per Aagaard (10) Michael Kjaer (1) S. Peter Magnusson (1) (2)
关键词：Master athletes ; Life ; long ; Endurance training ; AGE ; Aging
刊名：AGE
出版年：2014
出版时间：August 2014
年：2014
卷：36
期：4
全文大小：490 KB
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作者单位：Christian Couppé (1) (2) René B. Svensson (1) Jean-Francois Grosset (3) (4) Vuokko Kovanen (5) Rie H. Nielsen (1) Morten R. Olsen (1) Jytte O. Larsen (6) Stephan F. E. Praet (7) Dorthe Skovgaard (1) (8) Mette Hansen (1) (9) Per Aagaard (10) Michael Kjaer (1) S. Peter Magnusson (1) (2) 1. Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Bldg. 8, Bispebjerg Bakke 23, DK-2400, Copenhagen, NV, Denmark 2. Department of Physical Therapy, Musculoskeletal Rehabilitation Research Unit, Bispebjerg Hospital, Copenhagen, Denmark 3. CNRS UMR 7338, Biomécanique et Bioingénierie, Université de Technologie de Compiègne, 60205, Compiègne cedex, France 4. UFR de Santé, Médecine et Biologie Humaine, Université Paris 13, Sorbonne Paris Cité, 93017, Bobigny, France 5. Department of Health Sciences, University of Jyv?skyl?, Jyv?skyl?, Finland 6. Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark 7. Department of Rehabilitation Medicine, MOVEFIT- Sports Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands 8. Cluster for Molecular Imaging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark 9. Section for Sports Science, Department of Public Health, Aarhus University, Aarhus, Denmark 10. Institute of Sports Science and Clinical Biomechanics, SDU Muscle Research Cluster, University of Southern Denmark, Odense, Denmark
ISSN：1574-4647

文摘

Life-long regular endurance exercise is known to counteract the deterioration of cardiovascular and metabolic function and overall mortality. Yet it remains unknown if life-long regular endurance exercise can influence the connective tissue accumulation of advanced glycation endproducts (AGEs) that is associated with aging and lifestyle-related diseases. We therefore examined two groups of healthy elderly men: 15 master athletes (64?±-?years) who had been engaged in life-long endurance running and 12 old untrained (66?±-?years) together with two groups of healthy young men; ten young athletes matched for running distance (26?±-?years), and 12 young untrained (24?±-?years). AGE cross-links (pentosidine) of the patellar tendon were measured biochemically, and in the skin, it was assessed by a fluorometric method. In addition, we determined mechanical properties and microstructure of the patellar tendon. Life-long regular endurance runners (master athletes) had a 21?% lower AGE cross-link density compared to old untrained. Furthermore, both master athletes and young athletes displayed a thicker patellar tendon. These cross-sectional data suggest that life-long regular endurance running can partly counteract the aging process in connective tissue by reducing age-related accumulation of AGEs. This may not only benefit skin and tendon but also other long-lived protein tissues in the body. Furthermore, it appears that endurance running yields tendon tissue hypertrophy that may serve to lower the stress on the tendon and thereby reduce the risk of injury.

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