MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?

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• 作者：Yvan Devaux (1) <br> Pascal Stammet (2) <br> Hans Friberg (3) <br> Christian Hassager (4) <br> Michael A Kuiper (5) <br> Matt P Wise (6) <br> Niklas Nielsen (7) <br> for the Biomarker subcommittee of the TTM trial (Target Temperature Management After Cardiac Arrest ; NCT01020916) <br><br>1. Laboratory of Cardiovascular Research ; Luxembourg Institute of Health ; L-1526 ; Luxembourg ; Luxembourg <br> 2. Department of Anaesthesia and Intensive Care Medicine ; Centre Hospitalier ; L-1445 ; Luxembourg ; Luxembourg <br> 3. Skane University Hospital ; Lund University ; SE-205 02 ; Malmo ; Sweden <br> 4. Department of Cardiology ; The Heart Center ; Rigshospitalet ; DK - 2100 ; Copenhagen ; Denmark <br> 5. Department of Intensive Care Medicine ; Medical Center Leeuwarden ; 8934 AD ; Leeuwarden ; The Netherlands <br> 6. Adult Critical Care ; University Hospital of Wales ; Cardiff ; CF14 4XW ; UK <br> 7. Helsingborg Hospital ; Lund University ; S-251 87 ; Helsingborg ; Sweden <br>
• 刊名：Critical Care
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：19
• 期：1
• 全文大小：917 KB
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• 刊物主题：Intensive / Critical Care Medicine; Emergency Medicine;
• 出版者：BioMed Central
• ISSN：1364-8535

文摘

Despite advances in resuscitation medicine, including target temperature management as part of post-cardiac arrest care, many patients will have a poor neurological outcome, most often resulting in death. It is a commonly held belief that the ability to prognosticate outcome at an early stage after cardiac arrest would allow subsequent health care delivery to be tailored to individual patients. However, currently available predictive methods and biomarkers lack sufficient accuracy and therefore cannot be generally recommended in clinical practice. MicroRNAs have recently emerged as potential biomarkers of cardiovascular diseases. While the biomarker value of microRNAs for myocardial infarction or heart failure has been extensively studied, less attention has been devoted to their prognostic value after cardiac arrest. This review highlights the recent discoveries suggesting that microRNAs may be useful both to predict outcome and to treat patients after cardiac arrest.