Stress-induced premature senescence: from biomarkers to likeliness of in vivo occurrence

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• 作者：Olivier Toussaint ; José Remacle ; Jean-Fran?ois Dierick ; Thierry Pascal ; Christophe Frippiat ; Véronique Royer ; Joao Pedro Magalhacs ; Stéphanie Zdanov and Florence Chainiaux
• 关键词：ageing ; fibroblast ; senescence ; stress
• 刊名：Biogerontology
• 出版年：2002
• 出版时间：January 2002
• 年：2002
• 卷：3
• 期：1-2
• 页码：13-17
• 全文大小：69 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Geriatrics and Gerontology
  Developmental Biology
  
• 出版者：Springer Netherlands
• ISSN：1573-6768

文摘

The similarities between the biomarkers of stress-induced premature senescence and replicative senescence are reviewed. The possibility of existence of `molecular scars', i.e. long-term changes observed after subcytotoxic stress and not observed in replicative senescence, is considered. Lastly, the likeliness of existence of stress-induced premature senescence in vivo is discussed. The possible effects on normal and pathological tissue ageing are predicted.