Decision-making under explicit risk is impaired in multiple sclerosis: relationships with ventricular width and disease disability
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- 作者：Ashley D Radomski ; Christopher Power ; Scot E Purdon ; Derek J Emery…
- 关键词：Multiple sclerosis ; Cognition ; Decision ; making ; Neuropsychological tests ; MRI ; Central atrophy
- 刊名：BMC Neurology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：742 KB
- 刊物主题：Neurology; Neurochemistry; Neurosurgery;
- 出版者：BioMed Central
- ISSN：1471-2377
文摘
Background Decision-making is an essential function of everyday life. Decision-making under explicit risk requires developing advantageous decision strategies based on fixed outcomes (e.g., probabilities of winning or losing a bet). Decision-making and its neural substrates have been rarely studied in MS. We expected performance in decision-making under risk to be lowered in MS patients, and negatively correlated with disease-related disability, cognition, and ventricular width.