d-Dimer elevation and adverse outcomes
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- 作者：Rim Halaby (1)
Christopher J. Popma (1)
Ander Cohen (2)
Gerald Chi (1)
Marcelo Rodrigues Zacarkim (1)
Gonzalo Romero (1)
Samuel Z. Goldhaber (3)
Russell Hull (4)
Adrian Hernandez (5)
Robert Mentz (5)
Robert Harrington (6)
Gregory Lip (7)
Frank Peacock (8)
James Welker (9)
Ignacio Martin-Loeches (10)
Yazan Daaboul (1)
Serge Korjian (1)
C. Michael Gibson (1) - 关键词：d ; Dimer ; Deep vein thrombosis ; Mortality ; Prognosis ; Pulmonary embolism
- 刊名：Journal of Thrombosis and Thrombolysis
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：39
- 期：1
- 页码：55-59
- 全文大小：169 KB
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Christopher J. Popma (1)
Ander Cohen (2)
Gerald Chi (1)
Marcelo Rodrigues Zacarkim (1)
Gonzalo Romero (1)
Samuel Z. Goldhaber (3)
Russell Hull (4)
Adrian Hernandez (5)
Robert Mentz (5)
Robert Harrington (6)
Gregory Lip (7)
Frank Peacock (8)
James Welker (9)
Ignacio Martin-Loeches (10)
Yazan Daaboul (1)
Serge Korjian (1)
C. Michael Gibson (1)
1. Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, East Campus, RW 459, Boston, MA, 02215, USA
2. King鈥檚 College Hospital, London, UK
3. Cardiovascular Division, Department of Medicine, Brigham and Women鈥檚 Hospital, Harvard Medical School, Boston, MA, USA
4. Department of Medicine Calgary, Foothills Hospital, Calgary, Canada
5. Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
6. Department of Medicine, Stanford University, Stanford, CA, USA
7. Centre for Cardiovascular Sciences, City Hospital, University of Birmingham, Birmingham, UK
8. Emergency Department, Baylor College of Medicine, Houston, TX, USA
9. Anne Arundel Medical Center, Anne Arundel Health System Research Institute, University of Maryland School of Medicine, Baltimore, MD, USA
10. Critical Care Centre, Corporaci贸 Sanit脿ria I Universit脿ria Parc Taul铆 Hospital De Sabadell Parc Taul铆, Barcelona, Spain - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Cardiology
Hematology - 出版者：Springer Netherlands
- ISSN：1573-742X
文摘
d-Dimer is a biomarker of fibrin formation and degradation. While a d-dimer within normal limits is used to rule out the diagnosis of deep venous thrombosis and pulmonary embolism among patients with a low clinical probability of venous thromboembolism (VTE), the prognostic association of an elevated d-dimer with adverse outcomes has received far less emphasis. An elevated d-dimer is independently associated with an increased risk for incident VTE, recurrent VTE, and mortality. An elevated d-dimer is an independent correlate of increased mortality and subsequent VTE across a broad variety of disease states. Therefore, medically ill subjects in whom the d-dimer is elevated constitute a high risk subgroup in which the prospective evaluation of the efficacy and safety of antithrombotic therapy is warranted.