Older Persons with Diabetes Receive Fewer Inappropriate ICD Shocks: Results from the INTRINSIC RV Trial

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• 作者：Chirag M. Sandesara (1)
  Renee M. Sullivan (2)
  Andrea M. Russo (3)
  WeiWei Li (2)
  Arthur Kendig (2)
  John D. Day (4)
  Christopher Mullin (5)
  Kira Stolen (6)
  Brian Olshansky (2)
  
• 关键词：ICDs ; Diabetes ; Mortality ; Heart failure
• 刊名：Journal of Cardiovascular Translational Research
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：4
• 期：1
• 页码：27-34
• 全文大小：249KB
• 参考文献：1. Stein, K. M., Mittal, S., Gilliam, F. R., Gilligan, D. M., et al. (2009). Predictors of early mortality in implantable cardioverter-defibrillator recipients. / Europace, 11(6), 734-40. CrossRef
  2. Bunch, T. J., Day, J. D., Olshansky, B., et al. (2009). INTRINSIC RV Study Investigators: Newly detected atrial fibrillation in patients with an implantable cardioverter-defibrillator is a strong risk marker of increased mortality. / Heart Rhythm, 6(1), 2-. m.2008.09.025">CrossRef
  3. Cygankiewicz, I., Gillespie, J., Zareba, W., et al. (2009). MADIT II Investigators. Predictors of long-term mortality in Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) patients with implantable cardioverter-defibrillators. / Heart Rhythm, 6(4), 468-73. m.2008.12.023">CrossRef
  4. Lin, E. H., Heckbert, S. R., Rutter, C. M., Katon, W. J., Ciechanowski, P., Ludman, E. J., et al. (2009). Depression and increased mortality in diabetes: Unexpected causes of death. / Annals of Family Medicine, 7(5), 414-21. m.998">CrossRef
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  7. Wittenberg, S. M., Cook, J. R., & Hall, W. J. (2005). Comparison of efficacy of implanted cardioverter-defibrillator in patients with versus without diabetes mellitus. / The American Journal of Cardiology, 96(3), 417-19. mjcard.2005.03.090">CrossRef
  8. Whang, W., & Bigger, J. T., Jr. (2000). Diabetes and outcomes of coronary artery bypass graft surgery in patients with severe left ventricular dysfunction: Results from The CABG Patch Trial database. The CABG Patch Trial Investigators and Coordinators. / Journal of the American College of Cardiology, 36(4), 1166-172. CrossRef
  9. Olshansky, B., Day, J. D., Moore, S., et al. (2007). Is dual-chamber programming inferior to single-chamber programming in an implantable cardioverter-defibrillator? Results of the INTRINSIC RV (Inhibition of Unnecessary RV Pacing With AVSH in ICDs) study. / Circulation, 115(1), 9-6. CrossRef
  10. Olshansky, B., Day, J., McGuire, M., et al. (2006). Reduction of right ventricular pacing in patients with dual-chamber ICDs. / Pacing and Clinical Electrophysiology, 29(3), 237-43. CrossRef
  11. Bhavnani, S. P., Kluger, J., Coleman, C. I., et al. (2010). Prognostic impact of shocks for clinical and induced arrhythmias on morbidity and mortality among patients with implantable cardioverter-defibrillators. / Heart Rhythm, 7(6), 755-60. m.2010.02.039">CrossRef
  12. Poole, J. E., Johnson, G. W., Hellkamp, A. S., et al. (2008). Prognostic importance of defibrillator shocks in patients with heart failure. / The New England Journal of Medicine, 359(10), 1009-017. CrossRef
  13. Desai, H., Aronow, W. S., Ahn, C., et al. (2010). Risk factors for appropriate cardioverter-defibrillator shocks, inappropriate cardioverter-defibrillator shocks, and time to mortality in 549 patients with heart failure. / The American Journal of Cardiology, 105(9), 1336-338. mjcard.2009.12.057">CrossRef
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  18. Olshansky, B., Telfer, E. A., Curtis, A. B., et al. (2000). Predictive value of preoperative left ventricular ejection fraction and functional class for mortality and morbidity after high-risk coronary artery bypass grafting. / The American Journal of Cardiology, 85(12), 1489-491. A7. CrossRef
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  21. Saeed, M., Neason, C. G., Razavi, M., et al. (2010). Programming antitachycardia pacing for primary prevention in patients with implantable cardioverter defibrillators: Results from the PROVE Trial. / Journal of Cardiovascular Electrophysiology, in press. doi:10.1111/j.1540-8167.2010.01825.x .
  
• 作者单位：Chirag M. Sandesara (1)
  Renee M. Sullivan (2)
  Andrea M. Russo (3)
  WeiWei Li (2)
  Arthur Kendig (2)
  John D. Day (4)
  Christopher Mullin (5)
  Kira Stolen (6)
  Brian Olshansky (2)
  
  1. Virginia Cardiovascular Associates, 8100 Ashton Ave, STE 200, Manassas, VA, 20109, USA
  2. University of Iowa Hospitals and Clinics, 200 Hawkins Drive 4426a JCP, Iowa, IA, 52242, USA
  3. Cooper University Hospital, One Cooper Plaza Camden, Cooper, NJ, 08103, USA
  4. Utah Heart Clinic, 324 10th Ave Ste 206, Salt Lake, UT, USA
  5. The Integra Group, 8525 Edinbrook Crossing, Brooklyn Park, MN, 55443, USA
  6. Boston Scientific Corp, 1 Scimed Place, Maple Grove, MN, USA
  
• ISSN：1937-5395

文摘

In patients with heart disease, diabetes and age predict adverse outcomes. It remains unclear whether persons with diabetes who have implantable cardioverter defibrillators (ICDs) have fewer appropriate and inappropriate ICD shocks. The objective of this study is to determine if persons with diabetes who have ICDs receive a similar amount of appropriate and inappropriate shocks compared to persons without diabetes. In a post hoc analysis of 1,528 patients enrolled in the INTRINSIC RV trial, all-cause mortality and ICD shocks between persons with and without diabetes, stratified by age, was compared. The relationship between shock and mortality was also assessed. Mortality 1?year after ICD implant was lower for persons without diabetes vs. persons with diabetes (3.5% vs. 7.9%, p-lt;-.001). Young and old persons with diabetes received a similar number of total and appropriate ICD shocks. However, older persons with diabetes were less likely to receive inappropriate ICD shocks vs. older persons without diabetes (1.9% vs. 6.9%, p-lt;-.01). ICD shocks were not temporally related to mortality regardless of diabetes status. In the INTRINSIC RV trial, persons with diabetes and older persons without diabetes undergoing ICD implant were at a higher risk of death. Older persons with diabetes received less inappropriate shocks and still had a similar amount of appropriate shocks compared to persons without diabetes of similar age.