Upregulated Pdx1 and MafA Contribute to β-Cell Function Improvement by Sleeve Gastrectomy

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• 作者：Feng Li ; Han Cao ; Chunjun Sheng ; Hang Sun ; Kexiu Song ; Shen Qu
• 关键词：Sleeve gastrectomy ; Pdx1 ; MafA ; Pancreatic β cell ; GLP ; 1
• 刊名：Obesity Surgery
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：26
• 期：4
• 页码：904-909
• 全文大小：667 KB
• 参考文献：1.Eickhoff H, Guimarães A, Louro TM, Seiça RM, Castro E, Sousa F. Insulin resistance and beta cell function before and after sleeve gastrectomy in obese patients with impaired fasting glucose or type 2 diabetes. Surg Endosc. 2015;29(2):438–43.CrossRef PubMed
  2.Kaneto H, Matsuoka TA. Role of pancreatic transcription factors in maintenance of mature β-cell function. Int J Mol Sci. 2015;16(3):6281–97.CrossRef PubMed PubMedCentral
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  4.Bruinsma BG, Uygun K, Yarmush ML, Saeidi N. Surgical models of Roux-en-Y gastric bypass surgery and sleeve gastrectomy in rats and mice. Nat Protoc. 2015;10(3):495–507.CrossRef PubMed PubMedCentral
  5.Zhang Z, Zhang H, Li B, Meng X, Wang J, Zhang Y, et al. Berberine activates thermogenesis in white and brown adipose tissue. Nat Commun. 2014;5:5493.CrossRef PubMed
  6.Li F, Su Y, Cheng Y, Jiang X, Peng Y, Li Y, et al. Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development. Endocrinology. 2015;156(1):48–57.CrossRef PubMed
  7.Carter JD, Dula SB, Corbin KL, Wu R, Nunemaker CS. A practical guide to rodent islet isolation and assessment. Biol Proc Online. 2009;11:3–31.CrossRef
  8.Grong E, Kulseng B, Arbo IB, Nord C, Eriksson M, Ahlgren U, Mårvik R. Sleeve gastrectomy, but not duodenojejunostomy, preserves total beta-cell mass in Goto-Kakizaki rats evaluated by three-dimensional optical projection tomography. Surg Endosc. 2015.
  9.Al-Sabah S, Alasfar F, Al-Khaledi G, Dinesh R, Al-Saleh M, Abul H. Incretin response to a standard test meal in a rat model of sleeve gastrectomy with diet-induced obesity. Obes Surg. 2014;24(1):95–101.CrossRef PubMed
  10.Krieger JP, Arnold M, Pettersen KG, Lossel P, Langhans W, Lee SJ. Knockdown of GLP-1 receptors in vagal afferents affects normal food intake and glycemia. Diabetes. 2015.
  
• 作者单位：Feng Li (1)
  Han Cao (1)
  Chunjun Sheng (1)
  Hang Sun (1)
  Kexiu Song (1)
  Shen Qu (1)
  
  1. Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tong-Ji University, 301 Middle Yan-Chang Road, Shanghai, 200072, China
  
• 刊物主题：Surgery;
• 出版者：Springer US
• ISSN：1708-0428

文摘

Purpose Sleeve gastrectomy is an effective technique for the treatment of severe obesity, and its effects on the improved β-cell function have not yet been fully understood.