Assessment of Progression and Treatment Response of Optic Pathway Glioma with Positron Emission Tomography using α-[11C]Methyl-l-Tryptophan

详细信息    查看全文

• 作者：Fangyu Peng (1) (2) (3)
  Csaba Juhasz (1) (4)
  Kanta Bhambhani (1) (3)
  Dafang Wu (2) (3)
  Diane C. Chugani (1) (2)
  Harry T. Chugani (1) (2) (4)
  
• 关键词：Optical pathway glioma ; Positron emission tomography ; α ; [11C]Methyl ; l ; tryptophan
• 刊名：Molecular Imaging and Biology
• 出版年：2007
• 出版时间：May 2007
• 年：2007
• 卷：9
• 期：3
• 页码：106-109
• 全文大小：209KB
• 参考文献：1. Thiagalingam S, Flaherty M, Billson F, et al. (2004) Neurofibromatosis type 1 and optic pathway gliomas. Ophthalmology 111:568-77 ternal" href="http://dx.doi.org/10.1016/j.ophtha.2003.06.008">CrossRef
  2. Singhal S, Birch JM, Kerr B, et al. (2002) Neurofibromatosis type 1 and sporadic optic gliomas. Arch Dis Child 87:65-0 ternal" href="http://dx.doi.org/10.1136/adc.87.1.65">CrossRef
  3. Hoffman HJ, Humphreys RP, Drake JM, et al. (1992) Optic pathway/hypothalamic gliomas: A dilemma in management. Pediatr Neurosurg 19:186-89 ternal" href="http://dx.doi.org/10.1159/000120729">CrossRef
  4. Listernick R, Louis DN, Packer RJ, Gutamann DH (1997) Optic pathway gliomas in children with neurofibromatosis 1: Consensus statement from the NF1 optic pathway glioma task force. Ann Neurol 41:143-49 ternal" href="http://dx.doi.org/10.1002/ana.410410204">CrossRef
  5. Chateil JF, Soussotte C, Pedespan JM, et al. (2001) MRI and clinical differences between optic pathway tumors in children with and without neurofibromatosis. Br J Radiol 74:24-1
  6. Benard F, Romsa J, Hustinx R (2003) Imaging gliomas with positron emission tomography and single-photon emission computed tomography. Semin Nucl Med 33:148-62 ternal" href="http://dx.doi.org/10.1053/snuc.2003.127304">CrossRef
  7. Juhász C, Chugani DC, Muzik O, et al. (2006) / In vivo uptake and metabolism of α-[¹¹C]methyl-type-small-caps">l -tryptophan in human brain tumors. J Cereb Blood Flow Metab 26:345-7 ternal" href="http://dx.doi.org/10.1038/sj.jcbfm.9600199">CrossRef
  8. Bergstroem M, Litton J, Bohm C, Blomquist G (1982) Determination of object contour from projections for attenuation correction in cranial positron emission tomography. J Comput Assist Tomogr 6:365-2 ternal" href="http://dx.doi.org/10.1097/00004728-198204000-00022">CrossRef
  9. Pietrzyk U, Herholz K, Fink G, et al. (1994) An interactive technique for three-dimensional image registration: Validation for PET, SPECT, MRI, and CT brain studies. J Nucl Med 35:2011-018
  10. Muzik O, Chugani DC, Chakraborty P, et al. (1997) Analysis of [^C-11]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate / in vivo. J Cereb Blood Flow Metab 17:659-69 ternal" href="http://dx.doi.org/10.1097/00004647-199706000-00007">CrossRef
  11. Chugani DC, Muzik O, Behen M, et al. (1999) Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Ann Neurol 45:287-95 ternal" href="http://dx.doi.org/10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO;2-9">CrossRef
  12. Packer RJ, Lange B, Ater J, et al. (1993) Carboplatin and vincristine for recurrent and newly diagnosed low-grade gliomas of childhood. J Clin Oncol 11:850-56
  13. Diksic M, Nagahiro S, Sourkes TL, Yamamoto YL (1990) A new method to measure brain serotonin synthesis / in vivo. I. Theory and basic data for a biological model. J Cereb Blood Flow Metab 9:1-2
  14. Chugani DC, Muzik O (2000) Alpha [C-11] methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism. J Cereb Blood Flow Metab 20:2- ternal" href="http://dx.doi.org/10.1097/00004647-200001000-00002">CrossRef
  
• 作者单位：Fangyu Peng (1) (2) (3)
  Csaba Juhasz (1) (4)
  Kanta Bhambhani (1) (3)
  Dafang Wu (2) (3)
  Diane C. Chugani (1) (2)
  Harry T. Chugani (1) (2) (4)
  
  1. The Carman & Ann Adams Department of Pediatrics, Wayne State University School of Medicine, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA
  2. Department of Radiology, Wayne State University School of Medicine, Detroit, MI, USA
  3. Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
  4. Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA
  

文摘

Purpose To report the utility of positron emission tomography (PET) with α-[11C]methyl-l-tryptophan (AMT) for monitoring progression and response to treatment of an isolated optic pathway glioma (OPG) in a 16-year-old girl. Procedures Positron emission tomography scanning of the brain was performed 20?minutes after intravenous administration of AMT. The AMT-PET images were reconstructed and examined for tumor uptake of the tracer in correlation with coregistered magnetic resonance images. Results The PET scan demonstrated increased uptake of AMT by OPG in a clinically symptomatic child whose magnetic resonance imaging (MRI) was inconclusive for morphological changes of the tumor. The tracer uptake was dramatically decreased on the images obtained after chemotherapy. Subsequently, AMT-PET revealed a new tumor lesion of increased AMT uptake when the patient developed vision problems and MRI showed no significant interval morphological changes. Significant vision improvement was observed after external beam radiotherapy for the newly identified tumor lesion. Conclusions Positron emission tomography with α-[11C]methyl-l-tryptophan may be useful for monitoring progression and response to treatment of OPGs, which needs to be further investigated in a prospective study of more patients, including those with neurofibromatosis.