Abnormal Fronto-striatal Connectivity in Children with Histories of Early Deprivation: A Diffusion Tensor Imaging Study

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• 作者：Michael E. Behen (1) (3)
  Otto Muzik (1) (2) (3) (5)
  Anita S. D. Saporta (1)
  Benjamin J. Wilson (1)
  Darshan Pai (4)
  Jing Hua (4)
  Harry T. Chugani (1) (3)
  
• 关键词：Orphan ; Early deprivation ; Fiber tracking ; Fronto ; striatal pathway
• 刊名：Brain Imaging and Behavior
• 出版年：2009
• 出版时间：September 2009
• 年：2009
• 卷：3
• 期：3
• 页码：292-297
• 全文大小：183KB
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• 作者单位：Michael E. Behen (1) (3)
  Otto Muzik (1) (2) (3) (5)
  Anita S. D. Saporta (1)
  Benjamin J. Wilson (1)
  Darshan Pai (4)
  Jing Hua (4)
  Harry T. Chugani (1) (3)
  
  1. Departments of Pediatrics, Children鈥檚 Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
  3. Departments of Neurology, Children鈥檚 Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
  2. Departments of Radiology, Children鈥檚 Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA
  5. PET Center, Children鈥檚 Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI, 48201, USA
  4. Department of Computer Science, Wayne State University, Detroit, MI, USA
  

文摘

An Inattentive/Overactive (I/O) behavioral phenotype has been reported in a significant percentage of children raised from birth in orphanages. While a number of studies have identified both functional and structural brain abnormalities in children raised from birth in orphanages, no published studies have evaluated potential neural correlates of the I/O phenotype. We applied diffusion tensor imaging (DTI) to 15 pre-teen children raised in orphanages in Eastern Europe or Asia and later adopted to the US. Fiber tracts were constructed from DTI data using probabilistic fiber tracking and the cortical fiber distribution of fibers originating from the head of the caudate was compared between the early deprivation (ED) group and 12 age-matched controls. The ED group showed a more diffuse connectivity pattern, especially in the right hemisphere, potentially related to incomplete neuronal pruning during development. These structural abnormalities may be associated with inattention and overactivity encountered in children with ED.