Functional neuroimaging in the preoperative evaluation of children with drug-resistant epilepsy

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• 作者：Sandeep Sood and Harry T. Chugani
• 关键词：Epilepsy surgery ; Children ; Neuroimaging ; PET ; SPECT ; Secondary epileptic foci ; [11C]flumazenil ; Alpha ; [11C]methyl ; l ; tryptophan
• 刊名：Child's Nervous System
• 出版年：2006
• 出版时间：August, 2006
• 年：2006
• 卷：22
• 期：8
• 页码：810-820
• 全文大小：428 KB

文摘

Functional neuroimaging Although the primary imaging modality in the management of epilepsy is magnetic resonance imaging MRI, functional neuroimaging with positron-emission tomography (PET) and single photon emission computed tomography (SPECT) often provides complementary information and, in a number of situations, provides unique information that cannot be obtained with MRI. The most commonly used PET tracers used for epilepsy evaluation are 2-deoxy-2-[18F]fluoro-d-glucose (FDG) and [11C]flumazenil (FMZ). Recently, interictal PET with alpha-[11C]methyl-l-tryptophan was found to be highly specific for the epileptic focus and can differentiate between epileptogenic and nonepileptogenic lesions in the same patient (e.g., in patients with tuberous sclerosis).