Safety assessment of trans-tympanic photobiomodulation

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• 作者：Tae-Hyun Moon ; Min Young Lee ; Jae Yun Jung ; Jin-Chul Ahn…
• 关键词：Cochlea ; Laser therapy ; Safety
• 刊名：Lasers in Medical Science
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：31
• 期：2
• 页码：323-333
• 全文大小：8,520 KB
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• 作者单位：Tae-Hyun Moon (1) (2)
  Min Young Lee (2) (3)
  Jae Yun Jung (4)
  Jin-Chul Ahn (5) (7)
  So-Young Chang (5)
  Phil-Sang Chung (4) (5)
  Chung-Ku Rhee (4)
  Yoon-Hwan Kim (1)
  Myung-Whan Suh (6)
  
  1. Department of Otolaryngology-Head & Neck Surgery, Cheong-Ju Saint Mary’s Hospital, Cheong-Ju, South Korea
  2. Department of Medical Laser Graduate School of Medicine, Dankook University, Juk-Jeon, South Korea
  3. KRESGE Hearing Research Institute, University of Michigan, Ann Arbor, MI, USA
  4. Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, Cheonan, South Korea
  5. Beckman Laser Institute-Korea, College of Medicine, Dankook University, Cheonan, South Korea
  7. Department of Biomedical Science, Biomedical Translational Research Institute, Dankook University, Cheonan, Chungnam, South Korea
  6. Department of Otorhinolaryngology-Head & Neck Surgery, Seoul National University Hospital, Seoul, 110-744, South Korea
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Medicine/Public Health, general
  Dentistry
  Laser Technology and Physics and Photonics
  Quantum Optics, Quantum Electronics and Nonlinear Optics
  Applied Optics, Optoelectronics and Optical Devices
  
• 出版者：Springer London
• ISSN：1435-604X

文摘

We evaluated functional and morphological changes after trans-tympanic laser application using several different powers of photobiomodulation (PBM). The left (L) ears of 17 rats were irradiated for 30 min daily over 14 days using a power density of 909.1 (group A, 5040 J), 1136.4 (group B, 6300 J), and 1363.6 (group C, 7560 J) mW/cm2. The right (N) ears served as controls. The safety of PBM was determined by endoscopic findings, auditory brainstem response (ABR) thresholds, and histological images of hair cells using confocal microscopy, and light microscopic images of the external auditory canal (EAC) and tympanic membrane (TM). Endoscopic findings revealed severe inflammation in the TM of C group; no other group showed damage in the TM. No significant difference in ABR threshold was found in the PBM-treated groups (excluding the group with TM damage). Confocal microscopy showed no histological difference between the AL and AN, or BL and BN groups. However, light microscopy showed more prominent edema, inflammation, and vascular congestion in the TM of BL ears. This study found a dose-response relationship between laser power parameters and TM changes. These results will be useful for defining future allowance criteria for trans-tympanic laser therapies. Keywords Cochlea Laser therapy Safety