Subthreshold attention-deficit/hyperactivity disorder is associated with functional impairments across domains: a comprehensive analysis in a large-scale community study

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• 作者：Soon-Beom Hong (1) (2) (3)
  Dominic Dwyer (1)
  Jae-Won Kim (3)
  Eun-Jin Park (4)
  Min-Sup Shin (3)
  Boong-Nyun Kim (3)
  Hee-Jeong Yoo (3)
  In-Hee Cho (5)
  Soo-Young Bhang (6)
  Yun-Chul Hong (7)
  Christos Pantelis (1) (2)
  Soo-Churl Cho (3)
  
• 关键词：Attention ; deficit/hyperactivity disorder ; Diagnostic and statistical manual of mental disorders ; Socioeconomic status ; Subthreshold
• 刊名：European Child & Adolescent Psychiatry
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：23
• 期：8
• 页码：627-636
• 全文大小：216 KB
• 参考文献：1. Achenbach TM (1991) Manual for the Child Behavior Checklist/4-18 and 1991 profile. University of Vermont, Department of Psychiatry, Burlington, VT
  2. Aelion CM, Davis HT, McDermott S, Lawson AB (2009) Soil metal concentrations and toxicity: associations with distances to industrial facilities and implications for human health. Sci Total Environ 407:2216-223 CrossRef
  3. Basch CE (2011) Inattention and hyperactivity and the achievement gap among urban minority youth. J Sch Health 81:641-49 CrossRef
  4. Chen A, Cai B, Dietrich KN, Radcliffe J, Rogan WJ (2007) Lead exposure, IQ, and behavior in urban 5- to 7-year-olds: does lead affect behavior only by lowering IQ? Pediatrics 119:e650–e658 CrossRef
  5. Cho SC, Hong YC, Kim JW, Park S, Park MH, Hur J, Park EJ, Hong SB, Lee JH, Shin MS, Kim BN, Yoo HJ, Cho IH, Bhang SY, Hahn S (2013) Association between urine cotinine levels, continuous performance test variables, and attention deficit hyperactivity disorder and learning disability symptoms in school-aged children. Psychol Med 43:209-19 CrossRef
  6. Cho SC, Kim BN, Kim JW, Kim HW, Choi HJ, Jung SW, Yang YH, Chungh DS, Go BJ, Kim BS, Shin MS, Yoo HI, Yoo HJ, Lee DW, Lee SE, Lee JY, Lee JW, Jeon SI, Jung HY, Hong JP, Hwang JW, Han SH (2007) The reliability and validity of Diagnostic Interview Schedule for Children Version IV-Korean version (DISC-IV). Korean J Child Adolesc Psychiatry 18:138-44
  7. Cho SC, Kim BN, Kim JW, Rohde LA, Hwang JW, Chungh DS, Shin MS, Lyoo IK, Go BJ, Lee SE, Kim HW (2009) Full syndrome and subthreshold attention-deficit/hyperactivity disorder in a Korean community sample: comorbidity and temperament findings. Eur Child Adolesc Psychiatry 18:447-57 CrossRef
  8. de Zeeuw P, Schnack HG, van Belle J, Weusten J, van Dijk S, Langen M, Brouwer RM, van Engeland H, Durston S (2012) Differential brain development with low and high IQ in attention-deficit/hyperactivity disorder. PLoS One 7:e35770 CrossRef
  9. DuPaul GJ, Power TJ, Anastopoulos AD, Reid R (1998) The ADHD Rating Scale-IV: checklists, norms, and clinical interpretation. Guilford Press, New York
  10. Faraone SV (2005) The scientific foundation for understanding attention-deficit/hyperactivity disorder as a valid psychiatric disorder. Eur Child Adolesc Psychiatry 14:1-0 CrossRef
  11. Faraone SV, Biederman J, Doyle A, Murray K, Petty C, Adamson JJ, Seidman L (2006) Neuropsychological studies of late onset and subthreshold diagnoses of adult attention-deficit/hyperactivity disorder. Biol Psychiatry 60:1081-087 CrossRef
  12. Faraone SV, Biederman J, Spencer T, Mick E, Murray K, Petty C, Adamson JJ, Monuteaux MC (2006) Diagnosing adult attention deficit hyperactivity disorder: are late onset and subthreshold diagnoses valid? Am J Psychiatry 163:1720-729 quiz 1859 CrossRef
  13. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1313-323 CrossRef
  14. Frazier TW, Youngstrom EA, Naugle RI (2007) The latent structure of attention-deficit/hyperactivity disorder in a clinic-referred sample. Neuropsychology 21:45-4 CrossRef
  15. Galera C, Cote SM, Bouvard MP, Pingault JB, Melchior M, Michel G, Boivin M, Tremblay RE (2011) Early risk factors for hyperactivity-impulsivity and inattention trajectories from age 17?months to 8?years. Arch Gen Psychiatry 68:1267-275 CrossRef
  16. Golden CJ (1978) The Stroop color and word test. Stoelting Company, Chicago
  17. Hackman DA, Farah MJ, Meaney MJ (2010) Socioeconomic status and the brain: mechanistic insights from human and animal research. Nat Rev Neurosci 11:651-59 CrossRef
  18. Haslam N, Williams B, Prior M, Haslam R, Graetz B, Sawyer M (2006) The latent structure of attention-deficit/hyperactivity disorder: a taxometric analysis. Aust N Z J Psychiatry 40:639-47 CrossRef
  19. Hasson R, Fine JG (2012) Gender differences among children with ADHD on continuous performance tests: a meta-analytic review. J Atten Disord 16:190-98 CrossRef
  20. Hong SB, Hong YC, Kim JW, Park EJ, Shin MS, Kim BN, Yoo HJ, Cho IH, Bhang SY, Cho SC (2013) Bisphenol A in relation to behavior and learning of school-age children. J Child Psychol Psychiatry 54:890-99
  21. Jhun HJ, Seo HG, Lee DH, Sung MW, Kang YD, Syn HC, Jun JK (2010) Self-reported smoking and urinary cotinine levels among pregnant women in Korea and factors associated with smoking during pregnancy. J Korean Med Sci 25:752-57 CrossRef
  22. Kaufman AS (1976) A four test short form of the WISC-R. Contemp Educ Psychol 1:180-96 CrossRef
  23. Kim MK, Kim ZS (1986) A study on the abbreviated form of the K-WISC. Seoul J Psychiatry 11:194-01
  24. Kim ZS, Lee YS, Lee MS (1994) Two- and four-subtest short forms of the Korean-Wechsler Adult Intelligence Scale. Seoul J Psychiatry 19:121-26
  25. Kret ME, De Gelder B (2012) A review on sex differences in processing emotional signals. Neuropsychologia 50:1211-221 CrossRef
  26. Larsson H, Anckarsater H, Rastam M, Chang Z, Lichtenstein P (2012) Childhood attention-deficit hyperactivity disorder as an extreme of a continuous trait: a quantitative genetic study of 8,500 twin pairs. J Child Psychol Psychiatry 53:73-0 CrossRef
  27. Levy F, Hay DA, McStephen M, Wood C, Waldman I (1997) Attention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a large-scale twin study. J Am Acad Child Adolesc Psychiatry 36:737-44 CrossRef
  28. Lubke GH, Hudziak JJ, Derks EM, van Bijsterveldt TC, Boomsma DI (2009) Maternal ratings of attention problems in ADHD: evidence for the existence of a continuum. J Am Acad Child Adolesc Psychiatry 48:1085-093 CrossRef
  29. McCarney SB (1996) The Learning Disability Evaluation Scale-renormed. Hawthorne Educational Services, Columbia
  30. Nigg JT, Knottnerus GM, Martel MM, Nikolas M, Cavanagh K, Karmaus W, Rappley MD (2008) Low blood lead levels associated with clinically diagnosed attention-deficit/hyperactivity disorder and mediated by weak cognitive control. Biol Psychiatry 63:325-31 CrossRef
  31. Nigg JT, Nikolas M, Mark Knottnerus G, Cavanagh K, Friderici K (2010) Confirmation and extension of association of blood lead with attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom domains at population-typical exposure levels. J Child Psychol Psychiatry 51:58-5 CrossRef
  32. Nomura Y, Marks DJ, Grossman B, Yoon M, Loudon H, Stone J, Halperin JM (2012) Exposure to gestational diabetes mellitus and low socioeconomic status: effects on neurocognitive development and risk of attention-deficit/hyperactivity disorder in offspring. Arch Pediatr Adolesc Med 166:337-43 CrossRef
  33. Nomura Y, Marks DJ, Halperin JM (2010) Prenatal exposure to maternal and paternal smoking on attention deficit hyperactivity disorders symptoms and diagnosis in offspring. J Nerv Ment Dis 198:672-78 CrossRef
  34. Oh KJ, Lee HR (1990) Development of Korean version of child behavior checklist (K-CBCL). Korean Research Foundation Report, Seoul
  35. Park KS, Yoon JY, Park HJ, Park HJ, Kwon KU (1996) Development of KEDI-WISC, individual intelligence test for Korean children. Korean Educational Development Institute, Seoul
  36. Pheula GF, Rohde LA, Schmitz M (2011) Are family variables associated with ADHD, inattentive type? A case-control study in schools. Eur Child Adolesc Psychiatry 20:137-45 CrossRef
  37. Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 164:942-48 CrossRef
  38. Shaffer D, Fisher P, Lucas CP, Dulcan MK, Schwab-Stone ME (2000) NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 39:28-8 CrossRef
  39. Shin MS, Hong KE, Kim ZS, Cho SC (1998) A standardization study of the Korean version of Learning Disability Evaluation Scale. J Korean Neuropsychiatr Assoc 37:1233-245
  40. Shin MS, Park MJ (2007) STROOP: Color and word test children’s version for ages 5-4. Hakjisa, Seoul
  41. So YK, Noh JS, Kim YS, Ko SG, Koh YJ (2002) The reliability and validity of Korean parent and teacher ADHD rating scale. J Korean Neuropsychiatr Assoc 41:283-89
  42. Stewart PW, Sargent DM, Reihman J, Gump BB, Lonky E, Darvill T, Hicks H, Pagano J (2006) Response inhibition during Differential Reinforcement of Low Rates (DRL) schedules may be sensitive to low-level polychlorinated biphenyl, methylmercury, and lead exposure in children. Environ Health Perspect 114:1923-929
  43. Taylor SJ, Barker LA, Heavey L, McHale S (2013) The typical developmental trajectory of social and executive functions in late adolescence and early adulthood. Dev Psychol 49:1253-265 CrossRef
  44. Thapar A, Cooper M, Eyre O, Langley K (2013) What have we learnt about the causes of ADHD? J Child Psychol Psychiatry 54:3-6 CrossRef
  45. Trent S, Davies W (2012) The influence of sex-linked genetic mechanisms on attention and impulsivity. Biol Psychol 89:1-3 CrossRef
  
• 作者单位：Soon-Beom Hong (1) (2) (3)
  Dominic Dwyer (1)
  Jae-Won Kim (3)
  Eun-Jin Park (4)
  Min-Sup Shin (3)
  Boong-Nyun Kim (3)
  Hee-Jeong Yoo (3)
  In-Hee Cho (5)
  Soo-Young Bhang (6)
  Yun-Chul Hong (7)
  Christos Pantelis (1) (2)
  Soo-Churl Cho (3)
  
  1. Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Parkville, VIC, Australia
  2. Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia
  3. Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak-No, Chongno-Gu, Seoul, Republic of Korea
  4. Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea
  5. Department of Psychiatry, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Republic of Korea
  6. Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, Republic of Korea
  7. Department of Preventive Medicine, Institute of Environmental Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
  
• ISSN：1435-165X

文摘

This study compared children who experience attention-deficit/hyperactivity disorder (ADHD) symptoms but do not meet criteria (i.e., subthreshold ADHD) with those with the full syndrome and healthy controls. Presence of ADHD symptoms was determined in a nationwide community sample of 921 children, aged 8-1?years. The main outcome measures comprised attentional symptoms, comorbidity profiles, academic performance, and neurocognitive ability (i.e., ADHD Rating Scale, Child Behavior Checklist, Learning Disability Evaluation Scale, and Stroop Color-Word Test, respectively). Subthreshold ADHD was equally prevalent in boys and girls, and more prevalent in low-income families. Throughout all the outcome measurements, subthreshold ADHD was both a significantly milder condition than full syndrome ADHD and a significantly more severe condition than non-ADHD status. The findings were consistent across the total as well as the subtest scores, and after correction for multiple comparisons (p?ADHD were found to experience significant symptoms and functional impairments. The results of this study support the clinical relevance of subthreshold ADHD in a childhood population. Subthreshold diagnostic criteria for ADHD may be more sensitive in detecting ADHD symptoms in girls than the full syndrome criteria, and subthreshold clinical, cognitive, and behavioral symptoms of ADHD may occur in a subset of children who are possibly more sensitive to their environment. Further consideration about the diagnostic threshold for ADHD may particularly benefit girls and children in low-income families.