An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect
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- 作者：Yu-Hui Liu ; Xian-Le Bu ; Chun-Rong Liang ; Ye-Ran Wang…
- 关键词：Alzheimer ; Amyloid ; beta ; N ; terminal antibody ; Oligomer ; Fibril ; Dust ; raising effect
- 刊名：Journal of Neuroinflammation
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：12
- 期：1
- 全文大小：3,728 KB
- 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
- 出版者：BioMed Central
- ISSN：1742-2094
文摘
Background Senile plaques consisting of amyloid-beta (Aβ) are the major pathological hallmark of Alzheimer’s disease (AD) and have been the primary therapeutic target. Immunotherapies, which are designed to remove brain Aβ deposits, increased levels of soluble Aβ and accelerated brain atrophy in some clinical trials, suggesting that the solubilization of Aβ deposition might facilitate the formation of more toxic Aβ oligomers and enhance neurotoxicity.